Serum galectin-3 as a potential marker for gastric cancer

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Daye ChengYunhui Li

Abstract

The identification of cancer biomarkers can advance the possibility for early detection and better monitoring of tumor progression. The aim of this study was to assess the diagnostic and prognostic value of serum galectin-3(Gal-3) in patients with gastric cancer (GC). We measured serum Gal-3 levels using ELISA method in 87 patients with GC, 53 patients with benign gastric lesions, and 51 healthy controls. Serum levels of Gal-3 in patients with GC were significantly higher than those in benign disease patients and healthy controls (P<0.001), but no difference was found between benign disease patients and healthy controls (P=0.635). Additionally, serum Gal-3 level was associated with lymph node metastasis (P=0.001) and distant metastasis (P<0.001), whereas it was not related to gender (P=0.204), age (P=0.269), tumor size (P=0.399), location (P=0.715), TNM stage (P=0.385), differentiation (P=0.135), or invasion depth (P=0.273). The Kaplan-Meier survival analysis revealed that overall survival rates in patients with high Gal-3 levels were not significantly different that those with low Gal-3 levels (P=0.099). Results of the current study suggests that serum Gal-3 represents a potential diagnostic marker for patients with GC, and ma...Continue Reading

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Citations

Oct 3, 2015·Human Immunology·Masoud ZeinaliMehdi Abedinzadeh
Apr 18, 2018·Critical Reviews in Clinical Laboratory Sciences·Arnold PiekHerman H W Silljé
Dec 8, 2015·Clinical Medicine Insights. Oncology·Hafiz Ahmed, Dina M M AlSadek
Dec 6, 2017·International Journal of Molecular Medicine·Rui DongHui Yuan
Apr 2, 2020·International Journal of Breast Cancer·Arooj ShafiqFatima K Rehman

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