Serum gamma-glutamyl transferase is a predictor of mortality in patients with acute myocardial infarction

Medicine
Jae Gyung KimKi-Bae Seung

Abstract

Gamma-glutamyl transferase (GGT) is involved in the pathogenesis of atherosclerosis and has been associated with adverse cardiovascular outcomes in patients with ischemic heart disease. However, the association between GGT and long-term mortality has not been studied in patients with acute myocardial infarction (AMI).A total of 2239 AMI patients for whom serum GGT values were available and who underwent percutaneous coronary intervention (PCI) were enrolled in the COREA-AMI (CardiOvascular Risk and idEntificAtion of potential high-risk population in Korean patients with AMI) registry. Patients with acute liver injury were excluded. Patients were classified into 2 groups according to normal (n = 1983) or elevated (n = 256) levels of serum GGT. The primary clinical outcome was all-cause mortality. The secondary outcome was cardiac death and recurrent non-fatal myocardial infarction (MI).The median follow-up period was 3.7 years, and both groups had similar characteristics. Patients with elevated GGT had significantly higher all-cause mortality compared to patients with normal GGT (21.9% vs. 14.4%, P = .001). The multivariate Cox proportional hazards model showed that elevated serum GGT level was independently correlated with mort...Continue Reading

References

Aug 14, 1987·Clinica Chimica Acta; International Journal of Clinical Chemistry·M Fahie-WilsonK Wilson
Nov 24, 2004·Clinical Chemistry and Laboratory Medicine : CCLM·Alfonso PompellaAldo Paolicchi
Sep 28, 2005·Circulation·Elfriede RuttmannUNKNOWN Vorarlberg Health Monitoring and Promotion Program Study Group
Nov 11, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Douglas S LeeRamachandran S Vasan
May 2, 2007·Circulation·Donald E CutlipUNKNOWN Academic Research Consortium
Sep 30, 2010·Internal and Emergency Medicine·Chiara LazzeriGian Franco Gensini
Nov 3, 2010·Journal of Atherosclerosis and Thrombosis·Okan Turgut, Izzet Tandogan
Oct 19, 2012·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Firat OzcanNihat Sen
Dec 19, 2012·Clinica Chimica Acta; International Journal of Clinical Chemistry·Maria FranziniRamachandran S Vasan
Jul 24, 2014·Circulation·Emily M BucholzHarlan M Krumholz
Mar 3, 2015·The American Journal of Cardiology·Vanessa S ReddyUNKNOWN Investigators of National Registry of Myocardial Infarction (NRMI) 4b–5

❮ Previous
Next ❯

Software Mentioned

SPSS
MedCalc

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.