PMID: 11634Nov 1, 1976

Serum gamma-glutamyl transpeptidase activity and urinary D-glucaric acid excretion in newborns in the first week of life. Effects of phenobarbital and nicethamide combination

Acta paediatrica Scandinavica
E TalafantA Pojerová

Abstract

High serum gamma-glutamyl transpeptidase activity was found in cord blood of newborn boys. This activity decreased to lower values on the 4th and 7th days. In newborns treated for 3 days following the birth with a combination of phenobarbital and nicethamide an increase of gamma-glutamyl transpeptidase activity occurred from the 4th to the 7th days. The 7th day levels were significantly higher when compared with the controls. Simultaneous determination of urinary glucaric acid excretion confirmed the induction of hepatic microsomal enzymes in glucuronic acid pathway. This could also be demonstrated by a pronounced decrease of serum bilirubin levels in groups receiving the enzyme inducers whether phenobarbital was administered intramuscularly or orally as sodium salt solution.

References

Feb 1, 1975·The Journal of Pediatrics·H BartelsI Vogel
Feb 1, 1975·American Journal of Clinical Pathology·G M ShoreB Combes
Jan 4, 1975·British Medical Journal·P J MartinD M Goldberg
Feb 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·B Bugge-AsperheimF Kiil
Jun 1, 1972·Clinica Chimica Acta; International Journal of Clinical Chemistry·S B Rosalki, D Rau
Sep 19, 1969·Deutsche medizinische Wochenschrift·G SzaszW Fritzsche

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Bilirubin, (4E,15E)-Isomer
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