Serum gamma-glutamyl transpeptidase activity in patients receiving chronic phenytoin therapy

Digestive Diseases and Sciences
E B KeeffeJ D Gabourel

Abstract

To better define the incidence and range of elevated gamma-glutamyl transpeptidase (GGT) activity in patients taking a drug known to induce hepatic microsomal enzymes, GGT was measured in the sera of 58 patients before and after six months of phenytoin therapy. Enzyme activity at six months was greater than baseline in 52 of 58 patients (90%). GGT activity (normal, 0-50 units/liter) was 45.2 +/- 9.9 (mean +/- SEM) at baseline and 135.8 +/- 18.1 after six months of therapy, a mean threefold increase (P less than 0.001). Of the 45 patients with normal baseline GGT activity, some had marked elevation of serum GGT activity with values rising over 200 units/liter in eight patients and over 300 units/liter in four patients. Mean serum GGT activity remained significantly elevated at 12 and 24 months. This elevation in GGT activity was not influenced by age, sex, or additional anticonvulsant drug therapy. Both baseline and six-month GGT activity was lowest in patients who drank no alcohol, higher in patients who drank 0-1 pint/week, and greatest in patients who drank greater than 1 pint/week. All 13 patients with elevated baseline GGT activity were regular users of alcohol and/or taking other enzyme-inducing drugs. In conclusion, incre...Continue Reading

References

Oct 15, 1976·Clinica Chimica Acta; International Journal of Clinical Chemistry·A W Skillen, A M Pierides
Sep 15, 1978·Klinische Wochenschrift·R HeipertzW Poser
Apr 1, 1979·British Journal of Clinical Pharmacology·E PeruccaA Richens
Jan 1, 1973·American Journal of Clinical Pathology·L M Ewen, J Griffiths
Oct 10, 1970·Lancet·M Zein, G Discombe
Oct 1, 1970·Acta Medica Scandinavica·A KonttinenA Louhija
Jul 1, 1980·The Journal of Pediatrics·H W AigesS Teichberg
Mar 14, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·J K AllenW J Hensley
Jan 1, 1981·Clinical Pharmacokinetics·B K Park, A M Breckenridge
Feb 12, 1983·British Medical Journal·R Penn, D J Worthington
Nov 1, 1960·Archives of Biochemistry and Biophysics·J A GOLDBARGA M RUTENBURG
Sep 1, 1960·Clinica Chimica Acta; International Journal of Clinical Chemistry·A SZEWCZUK, M ORLOWSKI

Citations

Nov 1, 1987·Digestive Diseases and Sciences·J A DiPalma, M A Bayne
Apr 1, 1988·Baillière's Clinical Gastroenterology·Dominique Pessayre, D Larrey
Sep 1, 1992·Seizure : the Journal of the British Epilepsy Association·M WallG Farrell
Apr 1, 1988·Journal of the American Academy of Dermatology·A K SilvermanR C Wong
Aug 13, 2013·Metabolic Syndrome and Related Disorders·Vesna Dimitrijevic-SreckovicTatjana Ille
Nov 10, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Alberto CorsiniMichele Bortolini
Dec 21, 2016·The American Journal of Gastroenterology·Paul Y KwoJoseph K Lim
Dec 1, 1995·Arquivos de neuro-psiquiatria·M HoshinoA Cukiert
Mar 31, 2009·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Pradumna JamjutePhilip Banfield
Sep 21, 2001·Critical Reviews in Clinical Laboratory Sciences·J B Whitfield

Related Concepts

Alcohol Consumption
Gamma-glutamyl transferase
Liver
Liver Function Tests
Hydantol

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Pediculosis pubis

Pediculosis pubis is a disease caused by a parasitic insect known as Pthirus pubis, which infests human pubic hair, as well as other areas with hair including eye lashes. Here is the latest research.

Rh Isoimmunization

Rh isoimmunization is a potentially preventable condition that occasionally is associated with significant perinatal morbidity or mortality. Discover the latest research on Rh Isoimmunization here.

Genetic Screens in iPSC-derived Brain Cells

Genetic screening is a critical tool that can be employed to define and understand gene function and interaction. This feed focuses on genetic screens conducted using induced pluripotent stem cell (iPSC)-derived brain cells. It also follows CRISPR-Cas9 approaches to generating genetic mutants as a means of understanding the effect of genetics on phenotype.

Enzyme Evolution

This feed focuses on molecular models of enzyme evolution and new approaches (such as adaptive laboratory evolution) to metabolic engineering of microorganisms. Here is the latest research.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Pharmacology of Proteinopathies

This feed focuses on the pharmacology of proteinopathies - diseases in which proteins abnormally aggregate (i.e. Alzheimer’s, Parkinson’s, etc.). Discover the latest research in this field with this feed.

Alignment-free Sequence Analysis Tools

Alignment-free sequence analyses have been applied to problems ranging from whole-genome phylogeny to the classification of protein families, identification of horizontally transferred genes, and detection of recombined sequences. Here is the latest research.

Related Papers

The Journal of Law, Medicine & Ethics : a Journal of the American Society of Law, Medicine & Ethics
Ronald A Lindsay
Regulatory Toxicology and Pharmacology : RTP
Christine M HuntTrevor G Gibbs
The Journal of Steroid Biochemistry and Molecular Biology
E S TomlinsonD J Back
© 2021 Meta ULC. All rights reserved