Serum gastrin in chronic renal failure: its relation to acid secretion, G-cell density, and upper gastrointestinal findings

Scandinavian Journal of Gastroenterology
K Ala-KailaT Paakkala

Abstract

The interrelations among fasting serum gastrin, serum creatinine, gastric acid secretion variables, and G-cell densities were analyzed in 47 patients with chronic renal failure (CRF). The patients also underwent gastroscopy and radiologic upper gastrointestinal barium examination. It is suggested that the hypergastrinemia seen in CRF is related to several factors: gastric acidity, grade of renal failure, G-cell density, and basal gastrin secretion rate. With regard to serum gastrin two different populations can be found, the cutting-off point being 300 ng/l. Although the group with high gastrin levels included significantly more patients with gastric body atrophy than the other group (4 of 11 versus of 1 of 36), most of them had no atrophy, which indicates that (an)other mechanism(s) is responsible for the hypergastrinemia. In the relation between serum gastrin and gastric acidity also, two differently behaving subgroups emerged. In the first, strong acidity change corresponded to minor gastrin change, whereas in the other, minor acidity change corresponded to marked gastrin change. The correlation coefficients between gastrin and acidity were high within both subgroups. During regular dialysis patients preserve the characteris...Continue Reading

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Citations

Feb 1, 1993·Digestive Diseases and Sciences·J Y Kang
Feb 1, 1995·British Journal of Clinical Pharmacology·U GladziwaU Klotz
May 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·I RantalaK Ala-Kaila
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Dec 30, 2015·Critical Reviews in Food Science and Nutrition·David C DallasJ Bruce German
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Jun 22, 2011·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·G GourcerolM Bouvier

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