PMID: 5132220Nov 1, 1971

Serum gastrin in duodenal ulcer. I. Basal levels and effect of food and atropine

Gut
M G KormanJ Hansky

Abstract

Fasting serum gastrin has been measured by radioimmunoassay in 72 patients with duodenal ulcer and compared with that in normals, patients with gastric ulcer, and with the Zollinger-Ellison syndrome. The mean (+/- SEM) gastrin levels were 15.7 +/- 1.5 pg/ml in the duodenal ulcer group, 32.1 +/- 4.3 pg/ml in normals, 118 +/- 18.1 pg/ml in gastric ulcer, and between 450 and 2,000 pg/ml in the Zollinger-Ellison syndrome. There were no difficulties in distinguishing simple ulcer from the Zollinger-Ellison syndrome as the presence of hyperchlorhydria in combination with hypergastrinaemia led to a confident diagnosis of the latter disease.The effect of protein, glucose, and cream feeding with and without atropine was also assessed in a group of these patients with duodenal ulcer. As in normals, there was no stimulation of gastrin release by either atropine alone, distilled water, glucose, or cream. However, protein alone produced a greater rise in serum gastrin levels compared with that in normals and prior atropinization augmented this response greatly in duodenal ulcer. This indicates an increased amount of releasable gastrin in the latter disease, the release of which, under basal conditions, is suppressed by the high acidity in t...Continue Reading

References

Dec 27, 1969·Lancet·J Hansky, M D Cain
Jun 1, 1971·Saishin igaku. Modern medicine·Y MatsuoT Tsushima
Jan 1, 1971·Scandinavian Journal of Gastroenterology·M G KormanJ Hansky
Feb 1, 1971·Australian and New Zealand Journal of Medicine·D J Byrnes, L Lazarus
Oct 1, 1969·Annals of Surgery·M J OrloffH Rosen
Jun 13, 1970·British Medical Journal·D J ByrnesL Lazarus
Feb 25, 1971·The New England Journal of Medicine·W L Trudeau, J E McGuigan
Feb 25, 1971·The New England Journal of Medicine·S A Berson, R S Yalow
Jan 1, 1971·Scandinavian Journal of Gastroenterology·S EmåsB Fyrö
Apr 3, 1971·British Medical Journal·M G KormanJ Hansky
Feb 1, 1969·American Journal of Surgery·L R Dragstedt
May 1, 1961·The Journal of Physiology·R A GREGORY, H J Tracy

Citations

Oct 1, 1976·The American Journal of Digestive Diseases·J H CaldwellS Cataland
Jun 1, 1976·The American Journal of Digestive Diseases·R S Fisher, G Boden
Jan 1, 1975·The American Journal of Digestive Diseases·C L SmithK Buchanan
Jun 26, 1975·The New England Journal of Medicine·J H Walsh, M I Grossman
Sep 1, 1972·Annals of Surgery·J C ThompsonE N Brandt
Oct 31, 1981·Minerva chirurgica·F ProcaccianteG Ribotta
Feb 1, 1978·European Journal of Clinical Investigation·O BrandsborgN J Christensen
Aug 1, 1973·Australian and New Zealand Journal of Medicine·J HanskyM G Korman
Mar 1, 1972·Gut·M G KormanJ Hansky
May 1, 1972·Gut·M G KormanJ Hansky
Jan 1, 1974·Gut·K G Wormsley
Aug 1, 1974·Gut·J R HayesK D Buchanan
Sep 1, 1980·Gut·V Walker, W H Taylor
Sep 1, 1974·The Journal of Clinical Investigation·S J KonturekF Stadil
Feb 1, 1979·The Journal of Clinical Investigation·M FeldmanJ H Walsh
Sep 20, 1979·World Journal of Surgery·H D BeckerA Schafmayer
Dec 1, 1973·The Australian and New Zealand Journal of Surgery·K J Hardy, P Grossberg
Jan 1, 1972·Scandinavian Journal of Gastroenterology·E Schrumpf, T Sand
Jan 1, 1989·Scandinavian Journal of Gastroenterology. Supplement·S DomschkeW Domschke
Jan 1, 1978·Scandinavian Journal of Gastroenterology·K C ChristensenJ F Rehfeld
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·C T Richardson
Jan 1, 1974·Current Medical Research and Opinion·P J RooneyJ Millar
Oct 12, 1974·Lancet·R I Wesdorp, J E Fischer
Jan 8, 1977·Lancet·R G Fiddian-Green
Jul 31, 1987·Biochemical and Biophysical Research Communications·P C Kothary, A I Vinik
Jan 1, 1972·Scandinavian Journal of Gastroenterology·B J BroughJ Hansky
Oct 1, 1973·Klinische Wochenschrift·T U Hausamen, W P Fritsch

Related Concepts

Atropine Sulfate Anhydrous
Differential Diagnosis
Dietary Carbohydrates
Ghee
Dietary Proteins
Duodenal Ulcer
Fasting
Nutrients
Gastrin
Anhydrous Dextrose

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