Serum GDF15, a Promising Biomarker in Obese Patients Undergoing Heart Surgery

Frontiers in Cardiovascular Medicine
Shreya SarkarJean-François Légaré

Abstract

Background: Obesity is a risk factor that negatively impacts outcomes in patients undergoing heart surgery by mechanisms that are not well-defined nor predicated on BMI alone. This knowledge gap has fuelled a search for biomarkers associated with cardiovascular diseases that could provide clinical insight to surgeons. One such biomarker is growth differentiation factor15(GDF15), associated with inflammation, metabolism, and heart failure outcomes but not yet examined in the context of obesity and cardiac surgery outcomes. Methods: Patients undergoing open-heart surgery were consented and enrolled for blood and tissue (atria) sampling at the time of surgery. Biomarker analysis was carried out using ELISA and western blot/qPCR, respectively. Biomarker screening was classified by inflammation(NLR, GDF15, Galectin3, ST2, TNFR2), heart failure(HF)/remodeling(NT-proBNP) and metabolism(glycemia, lipid profile). Patients were categorized based on BMI: obese group (BMI ≥30.0) and non-obese group(BMI 20.0-29.9). Subsequent stratification of GDF15 high patients was conservatively set as being in the 75th percentile. Results: A total of 80 patients undergoing any open-heart surgical interventions were included in the study. Obese (mean BMI...Continue Reading

Associated Clinical Trials

References

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Citations

Aug 10, 2021·American Journal of Physiology. Endocrinology and Metabolism·Christoffer MartinussenRune Ehrenreich Kuhre
Sep 28, 2021·Frontiers in Immunology·Huan LiPingan Zhang

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Methods Mentioned

BETA
Assay
protein assay
ELISA

Software Mentioned

GraphPad Prism
Image Lab

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