PMID: 18038711Nov 28, 2007

Serum ghrelin concentration, fasting time and feeding in infants

Journal of Pediatric Endocrinology & Metabolism : JPEM
F SavinoR Miniero

Abstract

Data on hormonal feeding control in infants in the first months of life according to the kind of feeding are scanty. To evaluate whether serum ghrelin could be involved in feeding behaviour control of breast-fed (BF) and formula fed (FF) infants. We studied 50 AGA healthy term infants aged 1-6 months of age. Serum ghrelin concentration was determined by RIA. Fasting time (measured as the difference between the time of the last meal and the time of blood collection) and number of meals were recorded. A positive correlation between serum ghrelin levels and fasting time emerged in FF infants (r = 0.752; p <0.001) but not in BF infants (r = 0.345; p = 0.072). Circulating ghrelin concentration correlates positively with fasting time in FF infants; these infants have higher serum ghrelin concentration, longer fasting time and fewer meals than BF infants. These observations suggest a possible influence of early feeding on mechanisms regulating satiety and feeding behaviour.

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Citations

Jul 16, 2011·International Journal of Pediatrics·F SavinoR Oggero
Apr 30, 2011·World Journal of Gastroenterology : WJG·F SavinoR Oggero
Jan 31, 2012·Early Human Development·F SavinoL Silvestro
Oct 24, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·F Savino, S A Liguori
Feb 15, 2013·Obesity·Jessica SchuelerD Enette Larson-Meyer

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Breast Feeding, Exclusive
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