Serum Ghrelin Levels in Saudi Obese Asthmatic School-Children-Correlation with Interleukin-4, Interleukin-5, and Interleukin-21

International Journal of Environmental Research and Public Health
Mohammed Saeed Al-AyedMohammed Helmy Faris Shalayel

Abstract

Ghrelin is a peptide hormone with direct or indirect effects on obesity and asthma. More data are required to understand the effect of ghrelin on the control and pathogenesis of these diseases. The aim of this study was to evaluate ghrelin levels in selected groups of children to identify the association between serum ghrelin, obesity, and the severity of asthma. The study included 401 school children selected from the Najran area and grouped into non-obese asthmatics, obese asthmatics, obese non-asthmatics and controls (non-obese non-asthmatics). Blood levels of ghrelin, interleukin (IL)-4, IL-5 and IL-21 were determined by ELISA. The mean ghrelin values were insignificantly increased in obese children compared with non-obese children. The highest blood ghrelin values were in the non-obese asthmatic group. Serum ghrelin, IL-4 and IL-21 levels were significantly increased in asthmatic children compared with non-asthmatic children (p < 0.05), and there were significant positive correlations between ghrelin and IL-4, IL-5, and IL-21 in asthmatic children. Furthermore, ghrelin, IL-4, and IL-21 levels were significantly higher in uncontrolled asthmatics compared with controlled-asthmatic children (p < 0.05). Asthma was the only sig...Continue Reading

References

Jun 1, 1992·European Journal of Immunology·P ParronchiS Romagnani
Feb 1, 1994·The Journal of Experimental Medicine·S DubucquoiM Capron
Jul 2, 2002·Archives of Internal Medicine·Don D SinS F Paul Man
Apr 15, 2004·Allergy·Matthew MasoliUNKNOWN Global Initiative for Asthma (GINA) Program
Nov 24, 2004·American Journal of Respiratory and Critical Care Medicine·Robert J HancoxMalcolm R Sears
Oct 20, 2005·Experimental Gerontology·Vishwa Deep Dixit, Dennis D Taub
Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yayoi HiromuraOsam Mazda
Apr 18, 2009·Pediatrics International : Official Journal of the Japan Pediatric Society·Yuki OkamatsuToyojiro Matsuishi
Jul 16, 2010·The Journal of Endocrinology·Keiko NakaharaNoboru Murakami
Sep 14, 2011·Sleep & Breathing = Schlaf & Atmung·Manuel Sánchez-de-la-TorreFerran Barbé
Dec 24, 2011·Turkish Neurosurgery·Mehmet ErşahınBerrak Cağlayan Yeğen
Mar 2, 2012·Allergy, Asthma & Immunology Research·Hasan YukselGonul Dinc
Jul 28, 2012·American Journal of Respiratory and Critical Care Medicine·Olga SidelevaAnne E Dixon
Aug 8, 2012·Journal of Human Reproductive Sciences·Kp Suresh, S Chandrashekara
Dec 25, 2012·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Agori TsarouchaKonstantinos I Gourgoulianis
Sep 27, 2013·Multidisciplinary Respiratory Medicine·Nazan CobanogluNerin Nadir Bahceciler
Dec 7, 2013·Jornal brasileiro de pneumologia : publicaça̋o oficial da Sociedade Brasileira de Pneumologia e Tisilogia·Doaa Mohammed YoussefEman Mohamed Elbehidy
Mar 22, 2014·Biomedical Reports·Fang GongWei Hong Shen
Apr 11, 2014·Experimental Biology and Medicine·Sveta MohananMichael Dulin
Jun 5, 2015·Molecular Metabolism·T D MüllerM H Tschöp
Jul 29, 2015·BMC Pulmonary Medicine·Maziar Moradi-LakehAli H Mokdad
Sep 28, 2016·Thorax·Dale T Umetsu
Dec 7, 2017·The American Journal of the Medical Sciences·Tian FuLiping Han
Feb 27, 2018·Pflügers Archiv : European journal of physiology·Mohammed Saeed Zayed Al-Ayed
Jul 31, 2018·Polish Archives of Internal Medicine·Sarah MietheHolger Garn
Oct 12, 2018·Proceedings of the National Academy of Sciences of the United States of America·Franziska MendeBirgitte Holst

❮ Previous
Next ❯

Citations

Apr 25, 2020·Biomolecules·Haba ElabadlahErnest A Adeghate
Feb 16, 2021·Frontiers in Immunology·Nimisha MathurJesse Roth

❮ Previous
Next ❯

Methods Mentioned

BETA
ELISA

Software Mentioned

SPSS

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Shunsuke OhnishiKenji Kangawa
Nihon rinsho. Japanese journal of clinical medicine
Shunsuke OhnishiKenji Kangawa
Nihon rinsho. Japanese journal of clinical medicine
Masayasu Kojima, Kenji Kangawa
Nihon rinsho. Japanese journal of clinical medicine
Hiroshi Hosoda, Kenji Kangawa
© 2021 Meta ULC. All rights reserved