Serum gonadotropins and testosterone in men occupationally exposed to carbon disulfide

Journal of Toxicology and Environmental Health
G WägarE Helpiö

Abstract

Serum levels of gonadotropins and testosterone were determined for 69 men exposed to CS2 in viscose rayon production and for 22 nonexposed male controls. Mean ages of the two groups were 40 and 39 yr, respectively. The duration of exposure to CS2 ranged from 1 to 36 yr (mean, 12.5). Follicle stimulating hormone (FSH) levels were significantly higher among the exposed men than among the controls (13.6 versus 10.0 IU/l). The level of sex hormone binding globulin (SHBG) was significantly lower among the exposed men than among the controls (44 versus 53 nmol/l). Luteinizing hormone (LH) values were significantly higher among the 24-31 yr old exposed men than the controls of the same age. Levels of SHBG, of the free testosterone index, and of FSH and LH in men under 39 yr who had been exposed to CS2 for 1-9 yr differed significantly from those of their controls, whereas only FSH differed significantly among those exposed for 10 or more years in the same age group. In men aged 40 yr or more, after at least 10 yr of exposure, only FSH and LH were significantly higher than in the controls. Although the observed alterations do not seem to have any overt clinical implications for the study groups, they indicate that overall levels of CS2...Continue Reading

References

Jul 15, 1978·Clinica Chimica Acta; International Journal of Clinical Chemistry·M FrölichE C Brand
Jan 1, 1976·Scandinavian Journal of Haematology·G AsbjornsenA Aakvaag
Jul 1, 1968·The Journal of Clinical Endocrinology and Metabolism·H M Gandy, R E Peterson
Jun 1, 1974·The Journal of Clinical Endocrinology and Metabolism·R S Mecklenburg, R J Sherins
Apr 1, 1972·Journal of Steroid Biochemistry·A Vermeulen, L Verdonck
Nov 1, 1971·The Journal of Clinical Endocrinology and Metabolism·A VermeulenL Verdonck
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·D SparrowJ W Rowe
Mar 1, 1981·Journal of Toxicology and Environmental Health·G WägarE Helpiö

❮ Previous
Next ❯

Citations

Sep 1, 1993·Archives of Environmental Health·M VanhoorneD De Bacquer
Dec 4, 2003·Journal of Occupational Health·Toru TakebayashiUNKNOWN Japanese Rayon Worker's Health Study Group
May 1, 1996·Critical Reviews in Toxicology·S TasD Lison
Nov 1, 1996·Archives of Andrology·R De CelisA Feria-Velasco
Mar 19, 2013·Birth Defects Research. Part B, Developmental and Reproductive Toxicology·Marilyn Silva

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.