Serum GP73 combined AST and GGT reflects moderate to severe liver inflammation in chronic hepatitis B

Clinica Chimica Acta; International Journal of Clinical Chemistry
Mingjie YaoFengmin Lu

Abstract

Non-invasive method to identify chronic hepatitis B (CHB) patients with at least moderate inflammatory lesion but no increased ALT is an unmet need. We evaluated Golgi protein 73 (GP73) based hepatic inflammation model (HIM) as a serum surrogate for liver necroinflammatory activity, especially in those with ALT less than traditional upper concentration. The diagnostic performances of HIM were evaluated in 2 independent cohorts of liver biopsy proved CHB patients by receiver operating characteristic (ROC) curve analysis. HIM, a suggested index combined GP73, gamma-glutamyltransferase and AST, could significantly improve the diagnostic accuracy for liver necroinflammation (Area under ROC, AUROC: 0.890). More importantly, HIM still exhibit excellent diagnostic value (AUROC: 0.873) to identify patients with at least moderate liver necroinflammatory activity but with ALT <40 U/l. Serum GP73 was the major source of improvement for diagnostic model's accuracy. HIM is probably a promising non-invasive index to identify CHB patients with moderate to severe liver necroinflammation, especially in those with ALT <40 U/l.

Citations

Dec 17, 2020·Chinese Medical Journal·Ming-Jie YaoFeng-Min Lu
Oct 5, 2021·Journal of Biomaterials Science. Polymer Edition·Xifa LanLonggang Wang

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