Serum group I pepsinogen levels in patients with peptic ulcer and normal subjects

The Tohoku Journal of Experimental Medicine
C NakanomeY Goto

Abstract

Serum group I pepsinogen (PG I) levels were measured by radioimmunoassay in patients with peptic ulcer and normal subjects. The mean (+/-S.E.) serum PG I level in 318 normal subjects was 79 +/- 3 ng/ml. The level in males, 87 +/- 2 ng/ml (n = 246), was significantly higher than in females, 72 +/- 4 ng/ml (n = 72). The serum PG I levels in the patients with gastric ulcer and in those with duodenal ulcer were 91 +/- 7 ng/ml (n = 31) and 117 +/- 10 ng/ml (n = 31), respectively. Both values were significantly higher than the value in the subjects with endoscopically normal mucosa (63 +/- 5 ng/ml). No significant change in serum PG I was observed after subcutaneous injection of tetragastrin or after ingestion of meal. A significant correlation was found between serum PG I and stimulated pepsin output, peak pepsin output, and maximal acid output and peak acid output. These findings suggest that serum PG I may be determined by the chief cell mass.

Citations

Jun 17, 2015·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Eun Hye KimYong Chan Lee
Apr 11, 2014·The Tohoku Journal of Experimental Medicine·Katsunori IijimaTooru Shimosegawa

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