PMID: 43586Jan 1, 1979

Serum group I pepsinogens during prolonged infusion of pentagastrin and secretin in man

Scandinavian Journal of Gastroenterology
H L WaldumB K Straume

Abstract

Six 20- to 25-year-old healthy men were studied with an intravenous pentagastrin infusion in a dose of 6 micrograms/kg-h for 4.5 h. Four of these were also studied on separate days with an intravenous secretin infusion in a dose of 2 CU/kg-h for 4.5 h. Gastric juice was collected continuously for one 30-min period before and in 30-min periods throughout the infusion periods, and the gastric H+ and pepsin outputs were determined during the pentagastrin infusion only. Blood was drawn before, every 30 min throughout the infusion, and the next morning for determination of serum group I pepsinogens (PG I), serum gastrin, and plasma secretin. Pentagastrin evoked a sustained rise in gastric H+ and pepsin secretions, a more delayed and sustained increase in serum PG I in the four subjects with a normal pentagastrin-stimulated maximal gastric secretion, and a fall in serum PG I in the remaining two subjects with a low gastric secretion. Secretin also elicited a sustained elevation in serum PG I in all four examined, including one who showed a fall in serum PG I during pentagastrin infusion. It is proposed that pentagastrin may exert its stimulatory effect of pepsinogen synthesis subsequent to degranulation of the chief cells, whereas se...Continue Reading

References

Oct 1, 1988·Digestive Diseases and Sciences·C B LamersI M Samloff
Jan 1, 1981·Scandinavian Journal of Gastroenterology·H L Waldum, P G Burhol
Jan 1, 1980·Scandinavian Journal of Gastroenterology·H L Waldum, P G Burhol
Apr 25, 2013·International Journal of Cancer. Journal International Du Cancer·Reidar Fossmark, H L Waldum
Mar 25, 2015·Scandinavian Journal of Gastroenterology·Lars Aabakken
Apr 11, 2015·Scandinavian Journal of Gastroenterology·H L WaldumReidar Fossmark
Mar 27, 2001·Japanese Journal of Cancer Research : Gann·M TatemichiS Tsugane
Jul 1, 1983·Scandinavian Journal of Gastroenterology·O OktedalenH L Waldum
Jun 1, 1982·Scandinavian Journal of Gastroenterology·H H HauklandJ A Johnson

Citations

Sep 1, 1978·Gut·O B Schaffalitzky de Muckadell, J Fahrenkrug
Jan 1, 1979·Scandinavian Journal of Gastroenterology·H L WaldumP G Burhol
Oct 1, 1972·Scandinavian Journal of Clinical and Laboratory Investigation·J F RehfeldB Rubin
Jan 1, 1972·Scandinavian Journal of Gastroenterology·E Schrumpf, T Sand
Jan 1, 1969·Scandinavian Journal of Gastroenterology·A Berstad, H Petersen

Related Concepts

Pepsinogen B
Cellular Storage
Gastric Juice
Exertion
Pepsinogen Measurement
Pepsinogen A
Secretin Measurement
Pepsin 3
Process of Secretion
Secrepan

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