Serum heat shock protein 70 levels as a biomarker for inflammatory processes in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical
Patricia LechnerGabriele Multhoff

Abstract

Inflammatory and neurodegenerative processes are hallmarks of multiple sclerosis (MS). The synthesis of the major stress-inducible heat shock protein 70 (Hsp70) is induced by inflammation. The purpose of this study is to determine whether Hsp70 in serum can serve as a potential biomarker to distinguish inflammatory and neurodegenerative processes in MS. Serum was obtained from 94 patients: 26 clinically isolated syndrome (CIS), 40 relapsing-remitting MS (RRMS), 19 secondary progressive MS (SPMS), and nine primary progressive MS (PPMS). As controls, serum samples were collected from patients with non-inflammatory neurological diseases (NINDs, n = 41), other inflammatory neurological diseases (OINDs, n = 28) and healthy donors (HDs, n = 114). Serum levels of Hsp70 were quantified using the enzyme-linked immunosorbent assay detecting free and liposomal Hsp70 (lipHsp70 ELISA). Patients with MS displayed significantly higher Hsp70 serum levels than HDs (p < 0.001) and significantly lower levels than OINDs (p = 0.001). A subgroup analysis revealed that Hsp70 serum levels of CIS/RRMS patients are significantly higher than those of patients with progressive MS (SPMS/PPMS) (p < 0.05). Inflammation causes the release of Hsp70 into the bl...Continue Reading

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Citations

Nov 22, 2019·Frontiers in Molecular Biosciences·Kuldeep DhamaSunil Kumar Joshi
Jan 15, 2022·Molecular Neurobiology·Aleksandr V ZhuravlevElena V Savvateeva-Popova

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Methods Mentioned

BETA
enzyme-linked immunosorbent assay
ELISA

Software Mentioned

MATLAB

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