Serum heme-albumin: an allosteric protein

IUBMB Life
Paolo Ascenzi, Mauro Fasano

Abstract

Heme scavenging by plasma proteins, including serum albumin (SA), provides protection against free-heme oxidative damage, limits access by pathogens to the heme, and contributes to iron homeostasis by recycling the heme iron. In turn, serum heme-albumin (SA-heme) acquires heme-based ligand-binding and (pseudo-)enzymatic properties. Heme binding to SA and SA-heme reactivity are allosterically and competitively modulated by endogenous and exogenous third components, this being relevant in pharmacotherapy management.

References

Jul 15, 1975·Biochemical Pharmacology·E TsutsumiW A Mahon
May 16, 1989·Biochemistry·M C MardenQ H Gibson
Jun 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·J A HamiltonD M Small
Jan 1, 1994·Advances in Protein Chemistry·D C Carter, J X Ho
Oct 2, 1996·American Journal of Medical Genetics·L P ten Kate
Jun 25, 1999·Biochimica Et Biophysica Acta·Y I Miller, N Shaklai
Nov 26, 1999·Biochimica Et Biophysica Acta·S CurryN P Franks
Dec 11, 1999·Nucleic Acids Research·H M BermanP E Bourne
Nov 23, 2000·Bioconjugate Chemistry·T KomatsuE Tsuchida
Apr 4, 2001·The Journal of Biological Chemistry·I PetitpasS Curry
Jun 19, 2001·Biochimica Et Biophysica Acta·E MonzaniM Galliano
Jul 27, 2001·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·M FasanoS Aime
Feb 28, 2002·Biochemical and Biophysical Research Communications·Mark WardellDaniel C Carter
Apr 6, 2002·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·J K Amisha Kamal, Digambar V Behere
Jun 26, 2002·Biological & Pharmaceutical Bulletin·Ulrich Kragh-HansenMasaki Otagiri
Nov 12, 2002·Pharmaceutical Research·Victor Tuan Giam Chuang, Masaki Otagiri
Jan 11, 2003·Journal of Biomedical Materials Research. Part a·Eishun TsuchidaMakoto Suematsu
May 14, 2003·Proceedings of the National Academy of Sciences of the United States of America·Isabelle PetitpasStephen Curry
Jul 9, 2003·BMC Structural Biology·Patricia A ZunszainStephen Curry
Jan 17, 2004·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Patrik RydbergUlf Ryde
May 20, 2004·Biopolymers·Anna SułkowskaWiesław Sułkowski
Nov 4, 2004·Journal of the American Chemical Society·Teruyuki KomatsuEishun Tsuchida
Apr 9, 2005·IUBMB Life·Alessio BocediPaolo Ascenzi
Sep 20, 2005·Journal of Molecular Biology·Jamie GhumanStephen Curry
Dec 13, 2005·The FEBS Journal·Alessio BocediPaolo Ascenzi
Jan 6, 2006·IUBMB Life·Mauro FasanoPaolo Ascenzi
Mar 4, 2006·IUBMB Life·Paolo AscenziMauro Fasano
Apr 15, 2006·Mini Reviews in Medicinal Chemistry·Paolo AscenziMauro Fasano

❮ Previous
Next ❯

Citations

Aug 27, 2013·The Protein Journal·Mohammed J FarooqiLorenzo Brancaleon
Oct 20, 2010·Antioxidants & Redox Signaling·Paul W BuehlerAbdu I Alayash
Jul 25, 2014·Archives of Biochemistry and Biophysics·Elena Di MuzioPaolo Ascenzi
Sep 7, 2011·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Yu CaoMassimo Coletta
Sep 17, 2013·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Paolo AscenziMauro Fasano
Feb 16, 2016·Trends in Molecular Medicine·Lubka T RoumeninaJordan D Dimitrov
Oct 27, 2012·Journal of Inorganic Biochemistry·Gabriella FanaliMauro Fasano
Jan 11, 2012·Molecular Aspects of Medicine·Gabriella FanaliPaolo Ascenzi
Dec 14, 2011·Blood Cells, Molecules & Diseases·Sukanya SriiamDuncan R Smith
Jul 6, 2010·Biochemical and Biophysical Research Communications·Alessandro BolliPaolo Ascenzi
Mar 30, 2010·Biophysical Chemistry·Paolo Ascenzi, Mauro Fasano
Mar 10, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alessandra di MasiPaolo Ascenzi
Sep 4, 2015·Biochimica Et Biophysica Acta·Cristina N ButterfieldBradley M Tebo
Feb 1, 2012·Cellular Microbiology·Julie M WolfArturo Casadevall
May 11, 2011·IUBMB Life·Gabriella FanaliMauro Fasano
May 12, 2010·The FEBS Journal·Paolo AscenziMassimo Coletta
Apr 14, 2016·BMC Neurology·Steven M LeVine
Sep 25, 2012·Biochimica Et Biophysica Acta·Elena KarnaukhovaAbdu I Alayash
Jul 6, 2011·Biochemical and Biophysical Research Communications·Paolo AscenziMauro Fasano
May 23, 2016·Journal of Molecular Evolution·Antonio Emidio FortunatoNikos Andreakis
Jul 12, 2017·Expert Review of Proteomics·Shweta BhatMahesh J Kulkarni
Dec 8, 2017·Nature Communications·Fausto AlmeidaArturo Casadevall
May 4, 2016·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·Renato P MunhozAlfonso Fasano
Apr 21, 2018·European Biophysics Journal : EBJ·Courtney N JohnsonBorries Demeler
Jan 1, 2015·Cell Death Discovery·P AscenziM Fasano
Oct 10, 2020·Journal of Molecular Recognition : JMR·Giovanna De SimonePaolo Ascenzi
Feb 16, 2021·Frontiers in Immunology·Oluwabukola T GbotoshoGregory J Kato
Jul 18, 2016·Biochemistry and Biophysics Reports·Sarah C RozinekLorenzo Brancaleon
Jul 15, 2020·Molecular Aspects of Medicine·Alessandra di MasiPaolo Ascenzi
Sep 20, 2017·Journal of Inorganic Biochemistry·Paolo AscenziMassimo Coletta
May 24, 2021·Chemico-biological Interactions·Luciana M SergioKellen Brunaldi

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.