Serum hepatitis C RNA titers after liver transplantation are not correlated with immunosuppression or hepatitis

Transplantation
R B FreemanM M Kaplan

Abstract

The degree to which immunosuppression and/or rejection influences recurrent hepatitis C (HCV) after liver transplantation (LT) for end-stage HCV cirrhosis remains poorly defined. We quantified serum HCV-RNA in 84 serum samples from 28 anti-HCV-positive patients taken 223 days prior to and up to 1719 days after liver transplantation to determine if cumulative immunosuppression, rejection, or histologic recurrence correlated with HCV-RNA levels. Histologic, serum chemistry, cumulative steroid, and OKT3 and alpha-interferon (INF) dose data were collected at the time of HCV-RNA sampling. Eighteen of 24 evaluable patients (75%) had HCV-RNA detected in their sera after transplant. Eight patients had 14 rejection episodes, 9 patients received OKT3, and 5 were given INF for histologically moderate hepatitis. Five patients died - two of recurrent hepatitis C - and no retransplants were performed for recurrent hepatitis. Of the 23 survivors, 7 have histologic hepatitis - 2 with persistent ascites, and 2 with mild fibrosis. We could show no correlation between HCV-RNA levels and any of the variables examined although a trend toward increasing HCV-RNA levels with increasing numbers of rejection episodes was observed. In addition, histologi...Continue Reading

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Citations

Jul 18, 2000·Journal of Medical Virology·R TeixeiraA K Burroughs
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·A L DoughtyG W McCaughan
Feb 11, 1998·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·R LeonE R Schiff
Jan 29, 2000·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·S J PelletierT L Pruett
Jan 5, 2000·Transplantation Proceedings·G TisoneC U Casciani
Jun 11, 1999·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·S J CotlerS Kesten
Sep 11, 2002·Transplant Infectious Disease : an Official Journal of the Transplantation Society·S Einav, M J Koziel
May 12, 2001·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·M J GottschlichD K Moonka
Jan 19, 2002·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Giorgio BallardiniFrancesco Bianco Bianchi
Jan 15, 1997·Transplantation·H R Rosen, P Martin
Nov 26, 1999·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M G PessoaT L Wright
Dec 24, 1998·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M PrietoJ Berenguer
May 9, 2012·Transplantation Proceedings·M-H LinS-S Wang
Apr 24, 2007·The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation·Hina SahiMarie Budev
Mar 23, 2005·Reviews in Medical Virology·Christel Gremion, Andreas Cerny
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael G Hughes, Hugo R Rosen
Oct 20, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James R Burton, Hugo R Rosen
Oct 13, 2006·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alberto GrassiGiorgio Ballardini
Nov 25, 2004·Clinics in Liver Disease·M G Pessoa, T L Wright
Nov 26, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Laura LladóUNKNOWN THOSIN Study Group
Aug 30, 2014·World Journal of Gastroenterology : WJG·Alberto Grassi, Giorgio Ballardini
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