Serum Hepcidin Levels in Cognitively Normal Older Adults with High Neocortical Amyloid-β Load.

Journal of Alzheimer's Disease : JAD
Pratishtha ChatterjeeRalph N Martins

Abstract

Hepcidin, an iron-regulating hormone, suppresses the release of iron by binding to the iron exporter protein, ferroportin, resulting in intracellular iron accumulation. Given that iron dyshomeostasis has been observed in Alzheimer's disease (AD) together with elevated serum hepcidin levels, the current study examined whether elevated serum hepcidin levels are an early event in AD pathogenesis by measuring the hormone in cognitively normal older adults at risk of AD, based on high neocortical amyloid-β load (NAL). Serum hepcidin levels in cognitively normal participants (n = 100) aged between 65-90 years were measured using ELISA. To evaluate NAL, all participants underwent 18F-florbetaben positron emission tomography. A standard uptake value ratio (SUVR)<1.35 was classified as low NAL (n = 65) and ≥1.35 (n = 35) was classified as high NAL. Serum hepcidin was significantly higher in participants with high NAL compared to those with low NAL before and after adjusting for covariates: age, gender, and APOEɛ4 carriage (p < 0.05). A receiver operating characteristic curve based on a logistic regression of the same covariates, the base model, distinguished high from low NAL (area under the curve, AUC = 0.766), but was outperformed whe...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Nov 9, 1995·The New England Journal of Medicine·T PolvikoskiK Kontula
Oct 22, 2004·Nature Reviews. Neuroscience·Luigi ZeccaRobert R Crichton
Jan 24, 2007·Gastroenterology·Antonello PietrangeloChristian Trautwein
Oct 27, 2007·American Journal of Physiology. Gastrointestinal and Liver Physiology·Natalia P MenaMarco T Núñez
Apr 22, 2009·Neurology·Eduardo E Benarroch
Jan 12, 2010·Journal of Alzheimer's Disease : JAD·Mark A SmithGeorge Perry
Mar 13, 2013·Lancet Neurology·Victor L VillemagneUNKNOWN Australian Imaging Biomarkers and Lifestyle (AIBL) Research Group
May 1, 2013·Molecular Psychiatry·S C BurnhamUNKNOWN Australian Imaging, Biomarkers and Lifestyle Study Research Group
Nov 21, 2013·Acta Neuropathologica Communications·Animesh Alexander RahaRuma Raha-Chowdhury
Jan 16, 2014·PloS One·Luping ZhouUNKNOWN AIBL Research Group
May 23, 2014·Lancet Neurology·Bruno DuboisJeffrey L Cummings
Sep 27, 2014·Neurobiology of Aging·Pierrick BourgeatUNKNOWN AIBL Research Group
Apr 22, 2015·BMC Neuroscience·Ruma Raha-ChowdhuryAdrian Bomford
Nov 8, 2015·Journal of Neurochemistry·Abdel A Belaidi, Ashley I Bush
Mar 26, 2016·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Bruno DuboisUNKNOWN Proceedings of the Meeting of the International Working Group (IWG) and the American Alzheimer's Association on “The Preclin
Jun 23, 2016·Journal of Trace Elements in Medicine and Biology : Organ of the Society for Minerals and Trace Elements (GMS)·Tim Hofer, George Perry
Apr 8, 2017·Scientific Reports·Kathryn GoozeeRalph N Martins
Apr 13, 2017·Aging and Disease·Zohara SternbergMichael Garrick
Feb 9, 2018·Nature·Akinori NakamuraKatsuhiko Yanagisawa
Jun 25, 2019·Journal of the Neurological Sciences·Oh Joo KweonHye Ryoun Kim

❮ Previous
Next ❯

Citations

Aug 28, 2021·International Journal of Molecular Sciences·Irina BelayaKatja M Kanninen

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
blood drawn
ELISA
protein assay
sandwich immunoassay

Software Mentioned

SPSS
CapAIBL
package Deducer on
R

Related Concepts

Related Feeds

Alzheimer's Disease: APOE

Apolipoprotein E (APOE) polymorphic alleles are major genetic risk factors for Alzheimer's disease. Discover the latest research on APOE and other genetic determinants of Alzheimer's disease here.

CSF & Lymphatic System

This feed focuses on Cerebral Spinal Fluid (CSF) and the lymphatic system. Discover the latest papers using imaging techniques to track CSF outflow into the lymphatic system in animal models.

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

ApoE Phenotypes

Apolipoprotein E (APOE) is a protein involved in fat metabolism and associated with the pathogenesis of Alzheimer's disease and cardiovascular disease. Here is the latest research on APOE phenotypes.

Alzheimer's Disease: Amyloid Beta

Alzheimer's disease is a neurodegenerative disease associated with the accumulation of amyloid plaques in the brain; these plaques are comprised of amyloid beta deposits. Here is the latest research in this field.

Related Papers

[Rinshō ketsueki] The Japanese journal of clinical hematology
Tomas Ganz
Blood Cells, Molecules & Diseases
Jonathan M FlanaganErnest Beutler
Sheng wu gong cheng xue bao = Chinese journal of biotechnology
Hui Zhang, Qi-Peng Yuan
© 2022 Meta ULC. All rights reserved