Serum high-density lipoprotein cholesterol is a protective predictor of executive function in older patients with diabetes mellitus

Journal of Diabetes Investigation
Yue SunTimothy Kwok

Abstract

Older people with diabetes mellitus are at high risk for cognitive impairment or dementia. The clinical predictors for cognitive decline in older people with diabetes mellitus were elucidated. This was a secondary analysis of a vitamin B12 intervention trial in older people with diabetes mellitus. A total of 271 non-demented individuals were followed up at 9-month intervals for 27 months. We explored the association between baseline clinical features with changes in cognitive measures (Clinical Dementia Rating scale, Neuropsychological Test Battery including executive function z-scores, psychomotor speed z-scores and memory z-scores). A total of 152 participants had normal cognition (Clinical Dementia Rating 0) and 119 had cognitive impairment (Clinical Dementia Rating 0.5) at baseline. After 27 months, 41 participants had cognitive decline, 36 of whom were cognitively normal at baseline. Multiple logistic regression showed no significant clinical predictor of global cognitive decline. Higher high-density lipoprotein cholesterol (HDL-C) was associated with better executive performance at month 27 (β = 0.359, P < 0.001). Multilevel modeling showed that the highest tertile of HDL-C was associated with better executive function z-...Continue Reading

References

May 9, 1990·JAMA : the Journal of the American Medical Association·D M DreonP D Wood
May 23, 2001·JAMA : the Journal of the American Medical Association·UNKNOWN Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults
Sep 11, 2003·Journal of Neurotrauma·Andrew D KayMuriel J Caslake
Jun 3, 2005·The Journal of Nutrition·Jeff S VolekCassandra E Forsythe
Mar 25, 2006·Arteriosclerosis, Thrombosis, and Vascular Biology·Patrick C N Rensen, Louis M Havekes
Sep 12, 2007·Archives of Neurology·John HarrisonMichael Grundman
Apr 15, 2008·Medicine and Science in Sports and Exercise·Isabel C D RibeiroMarisa Passarelli
Jul 1, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Manjula Kurella TamuraWilliam McClellan
Jul 25, 2008·Diabetes Care·David G BruceTimothy M E Davis
Apr 16, 2009·JAMA : the Journal of the American Medical Association·Rachel A WhitmerJoseph V Selby
Jan 26, 2010·Physiology & Behavior·Ewan C McNay, Victoria E Cotero
Aug 21, 2010·Journal of the American Geriatrics Society·Ha T NguyenSara A Quandt
Jan 14, 2011·The New England Journal of Medicine·Amit V KheraDaniel J Rader
Jan 26, 2011·Nature Reviews. Endocrinology·Mark W J StrachanJacqueline F Price
Oct 26, 2011·Diabetic Medicine : a Journal of the British Diabetic Association·P P AungUNKNOWN Edinburgh Type 2 Diabetes Study Investigators
Nov 9, 2011·Nature Reviews. Endocrinology·Lei ChenPaul Z Zimmet
Jan 25, 2012·Current Diabetes Reviews·Hood ThabitSeamus Sreenan
Mar 7, 2012·Expert Review of Cardiovascular Therapy·Dan Farbstein, Andrew P Levy
Apr 28, 2012·Geriatrics & Gerontology International·Hiroyuki UmegakiUNKNOWN Japanese Elderly Diabetes Intervention Trial Study Group
Apr 24, 2013·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Akira NakamizoTomio Sasaki
Oct 10, 2013·Diabetes Care·Insa FeinkohlUNKNOWN Edinburgh Type 2 Diabetes Study (ET2DS) Investigators
Jan 8, 2014·Journal of Geriatric Psychiatry and Neurology·John P RyanCaterina Rosano
Apr 12, 2014·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Marie-Laure AncelinKaren Ritchie
Nov 5, 2014·Brain Structure & Function·Gabriel Gonzalez-EscamillaJose L Cantero
Dec 31, 2014·Cerebrovascular Diseases·Stephen D J MakinJoanna M Wardlaw
Feb 12, 2015·Journal of the American Medical Directors Association·SungChul LeeTakao Suzuki
Nov 9, 2016·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Timothy KwokLinda Lam
Mar 28, 2017·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Hiroshi YaoManabu Hashimoto

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BETA
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