Serum high-density lipoprotein cholesterol levels correlate well with functional but not with cognitive status in 85-year-old subjects.

The Journal of Nutrition, Health & Aging
Francesc FormigaRamón Pujol

Abstract

We evaluate the association between high-density lipoprotein cholesterol (HDL-C) levels and physical and cognitive performance indicators in 85-year-old subjects. Prospective cohort study. A community-based study. 321 subjects enrolled in the Octabaix Study. Functional status was determined using the Lawton-Brody Index (LI) and the Barthel Index (BI). Cognition was assessed using the modified Spanish version of the Mini-Mental State Examination (MEC). We also measured risks related to nutrition and falls, as well as comorbidity and chronic drug prescription. HDL-C serum concentrations <40 mg/dl for men and <46 mg/dl for women were used as cut-off values to discriminate between normal and low HDL-C concentrations. The sample consisted of 197 women (61%) and 124 men. Mean HDL-C levels were 56.5 ± 15 mg/dl, with gender differences being found (59.3 ± 15 mg/dl in women vs. 52.1 ± 13 mg/dl in men; p<0.0001). Sixty-one subjects (19%) had low HDL-C values. HDL-C levels correlated with BI (r=0.11, p=0.04) and LI (r=0.17, p=0.002) scores, but not with MEC scores (r=0.08, p=0.13). Poor BI and LI scores, lower MEC scores, a risk of falls and malnutrition, and polypharmacy were all associated with lower HDL-C values in the bivariate analys...Continue Reading

References

Feb 1, 1986·Journal of the American Geriatrics Society·M E Tinetti
Mar 1, 1993·Journal of the American Geriatrics Society·D M BuchnerS L Wolf
Mar 1, 1997·International Journal of Geriatric Psychiatry·G E WieringaA Burns
May 11, 2002·Science·Jim Oeppen, James W Vaupel
Jul 12, 2002·Annals of Neurology·Eric van ExelRudi G J Westendorp
Jul 16, 2003·Archives of Internal Medicine·Annelies W E Weverling-RijnsburgerRudi G J Westendorp
Oct 29, 2003·Archives of Internal Medicine·Anne B NewmanUNKNOWN Cardiovascular Health Study Research Group
Nov 24, 2004·Journal of Atherosclerosis and Thrombosis·Yasumichi Arai, Nobuyoshi Hirose
Jul 23, 2008·Perspectives in Vascular Surgery and Endovascular Therapy·Kimon Bekelis, Nicos Labropoulos
Jul 25, 2008·Arteriosclerosis, Thrombosis, and Vascular Biology·Anatol Kontush, M John Chapman
Jan 8, 2009·International Journal of Clinical Practice·L Cea-CalvoUNKNOWN Investigators of PREV-ICTUS study
Mar 2, 2010·Revista española de geriatría y gerontología·Assumpta FerrerUNKNOWN Grupo de Estudio OCTABAIX
Mar 20, 2010·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·G ZulianiL Ferrucci
Apr 27, 2010·Archives of Gerontology and Geriatrics·Elizabete Viana de FreitasAyrton Pires Brandão
Mar 3, 2011·The Journal of Nutrition, Health & Aging·F FormigaR Pujol

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Citations

Sep 4, 2015·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Linda EnrothMarja Jylhä
Dec 19, 2015·BioMed Research International·Cheng MaZhuowei Yu
Jul 16, 2014·International Psychogeriatrics·Janie CorleyIan J Deary
Nov 28, 2018·BMC Geriatrics·Nienke LegdeurPieter Jelle Visser
Jan 19, 2021·Curēus·Mehak Agarwal, Safeera Khan

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