Serum high-density lipoprotein cholesterol levels as a prognostic indicator in patients with idiopathic pulmonary arterial hypertension

The American Journal of Cardiology
Qin-hua ZhaoZhi-cheng Jing

Abstract

High-density lipoprotein (HDL) cholesterol levels are a strong, independent inverse predictor of cardiovascular disease. The present study aimed to determine whether serum HDL cholesterol levels correlated with disease severity and clinical outcomes in patients with idiopathic pulmonary arterial hypertension (IPAH). The serum HDL cholesterol levels were measured in 76 Chinese patients with IPAH and 45 healthy controls, together with other clinical variables. Univariate and multivariate Cox proportional hazards analysis was performed to assess the prognostic value of HDL cholesterol and event-free survival. Event-free survival was estimated using the Kaplan-Meier method. Serum HDL cholesterol levels were significantly decreased in patients with IPAH compared with controls (1.0 ± 0.3 vs 1.5 ± 0.3 mmol/L; p <0.001). The serum HDL cholesterol levels decreased in proportion to the severity of World Health Organization functional class. Compared to the high HDL cholesterol group, the low HDL cholesterol group demonstrated a significantly lower 6-minute walking distance, cardiac index, mixed venous saturation, and arterial carbon dioxide pressure but significantly greater pulmonary vascular resistance and serum uric acid levels. The s...Continue Reading

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Citations

Oct 27, 2015·Annals of the American Thoracic Society·Nadine Al-NaamaniUNKNOWN ASA-STAT Study Group
Jul 16, 2015·The Clinical Respiratory Journal·Ruijuan SunErdan Dong
Jun 14, 2016·The American Journal of Cardiology·Carolyn M LarsenGarvan C Kane
Jul 22, 2016·Respiratory Research·Anjum AnwarSoban Umar
Feb 16, 2017·Scientific Reports·Grzegorz KopećPiotr Podolec
Sep 30, 2016·Pulmonary Circulation·Salil SharmaMansoureh Eghbali
Aug 21, 2018·The Journal of Physiology·Conor WillsonAyako Makino
Dec 5, 2018·Canadian Journal of Physiology and Pharmacology·Mark A UnderwoodRobin H Steinhorn
Jul 20, 2019·Kardiologiia·V V Gaynitdinova, S N Avdeev
Sep 9, 2017·Oncotarget·Aurélie HautefortFrédéric Perros
Jul 22, 2019·International Journal of Molecular Sciences·Kamil Jonas, Grzegorz Kopeć
May 18, 2021·Pulmonary Circulation·Ghaleb KhirfanGustavo A Heresi

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