Serum high-density lipoprotein particles of alcohol-fed rats are deficient in apolipoprotein E

Hepatology : Official Journal of the American Association for the Study of Liver Diseases
R C LinV L Phelps

Abstract

Effects of chronic ethanol consumption on serum lipoproteins have been studied in the rat. The serum levels of triglycerides, cholesterol, phospholipids and apolipoproteins AI and AIV increased significantly after 1 week of ethanol feeding, and they remained elevated up to 7 weeks of alcohol drinking. By contrast, serum total apolipoprotein E decreased or, sometimes, did not change. Very-low-density lipoprotein cholesterol, triglycerides and very-low-density lipoprotein apolipoprotein E of the alcohol-fed rats increased in parallel and were about 2- to 2.5-fold over the controls. Whereas high-density lipoprotein cholesterol, phospholipids, apolipoprotein AI and AIV increased 1.2-fold by chronic alcohol feeding, the level of high-density lipoprotein apolipoprotein E decreased to 70% of that of the control rats. The rates of secretion of apolipoprotein AI, E and AIV into the culture medium by hepatocytes isolated from ethanol-fed rats were 1.8-, 1.3- and 1.1-fold higher than those from control rats. These data indicate that (i) chronic ethanol feeding increases very-low-density lipoprotein and high-density lipoprotein in the rat; (ii) serum high-density lipoprotein particles of the ethanol-fed rats are deficient in apolipoprotein...Continue Reading

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Citations

Dec 17, 2009·Genes & Nutrition·Raj LakshmanSamir Zakhari
Oct 18, 2003·Metabolism: Clinical and Experimental·Manjunath N RaoM Raj Lakshman
Mar 1, 1991·Alcoholism, Clinical and Experimental Research·R C Lin, L Lumeng
Dec 1, 1992·Alcoholism, Clinical and Experimental Research·R C LinL Lumeng
Oct 1, 1992·Alcoholism, Clinical and Experimental Research·R C LinL Lumeng
Oct 1, 1993·Metabolism: Clinical and Experimental·D W Crabb, R Sidhu
Apr 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·R C LinT J Kelly

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