Serum high mobility group box 1 protein levels are not associated with either histological severity or treatment response in children and adults with nonalcoholic fatty liver disease

PloS One
Katherine YatesNASH CRN

Abstract

Serum high mobility group box 1 protein (HMGB1) is a proinflammatory molecule that could potentially serve as a biomarker for non-alcoholic fatty liver disease (NAFLD) and non-alcoholic steatohepatitis (NASH) due to its correlation with degree of liver fibrosis. The aim of the current study was to examine the cross-sectional and longitudinal relationships between serum HMGB1 levels and liver histology in adults and children with NAFLD participating in two large randomized controlled trials. Serum HMGB1 levels were measured at various time points in adults and children with NAFLD, who participated in PIVENS and TONIC clinical trials respectively. PIVENS trial compared vitamin E or pioglitazone to placebo in adults whereas TONIC trial compared vitamin E or metformin to placebo in children. Participants had liver biopsies at baseline and the end of treatment (96 weeks), and liver histology was reviewed by a central committee of study pathologists. In the cross-sectional analyses (n = 205 for PIVENS and 109 for TONIC), there was no significant relationship between serum HMGB1 levels and histological features such as steatosis, ballooning, inflammation, fibrosis, or presence of steatohepatitis in either adults or children. Serum HMG...Continue Reading

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Citations

May 18, 2019·Endocrine Reviews·Matthew J WattMagdalene K Montgomery
Nov 4, 2020·Immunity, Inflammation and Disease·Bo LiKai Le
Jan 12, 2021·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Zhenyu WangShaoling Lin
Mar 31, 2021·Journal of Leukocyte Biology·Yuan-Ao NiQuan Gong

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Methods Mentioned

BETA
biopsy
ELISA
acetylation

Software Mentioned

Soft
Stata
max Pro
SAS
PIVENS

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