Serum HMGB1 associates with liver disease and predicts readmission and mortality in patients with alcohol use disorder.

Alcohol
Augustin G L VannierJay Luther

Abstract

Identifying the minority of patients with alcohol use disorder (AUD) who develop the wide spectrum of alcohol-associated liver disease (ALD), and risk-stratifying these patients, is of critical importance. High-Mobility Group Box 1 protein (HMGB1) is an alarmin that has been implicated in the pathogenesis of multiple liver diseases. Its use as a biomarker for liver disease in those with AUD has not been studied. In this report, we investigated the association between serum HMGB1 and the presence, severity, and progression of ALD in two well-characterized cohorts of patients with AUD. In our discovery cohort of 80 patients, we found that patients with AUD and ALD exhibited higher serum HMGB1 levels compared to patients with AUD only (p = 0.0002). Additionally, serum HMGB1 levels were positively associated with liver disease severity (p < 0.0001). We found that index serum HMGB1 levels were associated with liver disease progression, defined by an increase in MELD score at 120 days (p = 0.0397). Serum HMGB1 was notable for its diagnostic and prognostic ability; it proved able to distinguish accurately between severe and non-severe forms of ALD in both our discovery cohort (AUC = 0.8199, p = 0.0003) and an independent validation co...Continue Reading

References

Jan 1, 1997·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·S NaveauJ C Chaput
Jun 26, 2009·The New England Journal of Medicine·Michael R LuceyTimothy R Morgan
Jan 22, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Bin GaoSamir Zakhari
Apr 11, 2012·World Journal of Hepatology·Radan BruhaJaromir Petrtyl
Oct 25, 2012·Digestive Diseases·Gyongyi SzaboShashi Bala
Mar 21, 2013·Journal of Hepatology·Jürgen RehmKevin D Shield
Oct 5, 2013·American Journal of Physiology. Gastrointestinal and Liver Physiology·Yeon S SeoVijay H Shah
Feb 14, 2014·Immunologic Research·Yael Rosenberg-HassonHolden T Maecker
Jun 15, 2014·The Journal of Biological Chemistry·Xiaodong GeNatalia Nieto
Apr 23, 2015·The New England Journal of Medicine·Mark R ThurszUNKNOWN STOPAH Trial
Nov 29, 2015·Gastroenterology·Suthat Liangpunsakul, David W Crabb
Jul 1, 2016·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Tea Lund LaursenThomas Damgaard Sandahl
Nov 3, 2017·The Cochrane Database of Systematic Reviews·Chavdar S PavlovChristian Gluud
Feb 3, 2018·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Virendra SinghAkash Singh
May 12, 2018·Nature Reviews. Gastroenterology & Hepatology·Anupriya TripathiRob Knight
Sep 12, 2018·Hepatology Communications·Harriet GaskellNatalia Nieto
Feb 2, 2019·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Neil D ShahRamon Bataller
Mar 21, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Banishree SahaGyongyi Szabo
Jun 27, 2019·Clinical Liver Disease·Jessica L Mellinger
May 13, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jay LutherSuraj J Patel

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Nihon rinsho. Japanese journal of clinical medicine
Ikuro Maruyama, Shingo Yamada
Nihon rinsho. Japanese journal of clinical medicine
Ikuro Maruyama
© 2021 Meta ULC. All rights reserved