Serum homocysteine and asymmetric dimethylarginine levels in patients with premature ovarian failure: a prospective controlled study

Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology
Ibrahim GulhanErbil Dogan

Abstract

To investigate serum homocysteine and asymmetric dimethylarginine (ADMA) levels in patients with premature ovarian failure (POF). A total of 69 women, 32 with POF and 37 apparently healthy women were included in the study. Fasting blood samples were drawn to measure serum homocysteine and ADMA levels using ELISA method. The study and control group had a mean age of 37.3 + 2.6, 37.5 + 2.5 years; a mean homocysteine level of 13.54 + 5.19, 12.71 + 3.99 mmol/l and a mean ADMA level of 1.32 + 0.27, 1.26 + 0.36 mmol/l, respectively. There were no statistically significant differences between the two groups in terms of homocysteine and ADMA levels (with p values of 0.465 and 0.423, respectively). A negative significant correlation was found between estradiol and ADMA (p <0.05). Homocysteine and ADMA levels did not change in comparison with the control group, which suggests that estrogen deficiency in patients with POF does not have any effect on homocysteine and asymmetric dimethylarginine levels.

References

Feb 1, 1992·European Journal of Clinical Investigation·A AnderssonB Hultberg
Nov 1, 1985·Metabolism: Clinical and Experimental·L E BrattströmJ E Hardebo
Nov 15, 1995·JAMA : the Journal of the American Medical Association·O NygårdG Kvåle
Dec 8, 1993·JAMA : the Journal of the American Medical Association·J SelhubI H Rosenberg
Nov 1, 1995·European Journal of Clinical Investigation·M G WoutersT K Eskes
Jul 1, 1996·The Journal of Clinical Investigation·S R LentzD D Heistad
Jun 11, 1997·JAMA : the Journal of the American Medical Association·I M GrahamG Andria
Jul 24, 1997·The New England Journal of Medicine·O NygårdS E Vollset
Apr 16, 1998·The New England Journal of Medicine·G N Welch, J Loscalzo
Mar 8, 2000·Atherosclerosis·A E HakC D Stehouwer
Jul 13, 2002·American Journal of Obstetrics and Gynecology·Jonna S MadsenJørgen Jespersen
Feb 6, 2003·Fertility and Sterility·Noha H FaragPaul J Mills
Apr 4, 2003·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Bo AbrahamsenLeif Mosekilde
Dec 23, 2003·Clinica Chimica Acta; International Journal of Clinical Chemistry·Xiang Ping LiYan-Sheng Li
Feb 22, 2005·Current Drug Metabolism·Markus C Stühlinger, Olaf Stanger
Jun 1, 2005·European Journal of Obstetrics, Gynecology, and Reproductive Biology·F BruschiP G Crosignani
Oct 2, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Rogério Bonassi MachadoGeraldo Rodrigues De Lima
Jun 24, 2008·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Emmanuel Kalu, Nick Panay
Sep 16, 2008·Menopause : the Journal of the North American Menopause Society·Marieke O VerhoevenPeter Kenemans
Jan 29, 2009·The Journal of Clinical Endocrinology and Metabolism·Meryl S LeboffSteven Cummings

❮ Previous
Next ❯

Citations

May 7, 2016·Clinical and Experimental Hypertension : CHE·Jing-Jie ZhengFei-Yun Zheng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.