Serum Homocysteine and Behavioral and Psychological Symptoms of Dementia: Is There Any Correlation in Alzheimer's Disease?

Annals of Neurosciences
Ravi M SoniNeera Kohli

Abstract

There are studies showing the relation between serum B12, folate and Behavioral and Psychological symptoms of Dementia (BPSD) in Alzheimer's disease (AD). Serum levels of these vitamins do not reflect actual disease status and therefore checking the serum Homocysteine level is considered a better test. Homocysteine has been found to be associated with cognitive impairment and various psychiatric disorders. This study was planned to identify the correlation between serum homocysteine levels and BPSD in AD patients. AD patients (n = 18) and healthy controls (n = 18) were included in the study. Diagnosis of AD was confirmed using International Classification Disease-10. AD patients were assessed using Mini Mental Status Examination (MMSE), Clinical Dementia Rating scale (CDR), Global Deterioration scale (GDS), and Neuropsychiatric inventory (NPI). Healthy controls were assessed on MMSE and Mini International Neuropsychiatric Interview. Serum homocysteine, vitamin B12, and folate levels were measured in all study subjects. Patients with AD had statistically significant higher serum levels of homocysteine as compared to the control group, while the levels of vitamin B12 and folate did not differ significantly. There was statisticall...Continue Reading

References

Nov 1, 1975·Journal of Psychiatric Research·M F FolsteinP R McHugh
Dec 1, 1990·Journal of Neurology, Neurosurgery, and Psychiatry·T BottiglieriE H Reynolds
Sep 1, 1982·The American Journal of Psychiatry·B ReisbergT Crook
Jan 1, 1995·Journal of Neural Transmission. General Section·B ReglandM Medhus
Oct 24, 1997·Archives of General Psychiatry·G S AlexopoulosM Charlson
Apr 4, 2000·British Medical Bulletin·D G Weir, J M Scott
Jul 15, 2000·Journal of Neurology, Neurosurgery, and Psychiatry·T BottiglieriE H Reynolds
Jul 17, 2001·Dementia and Geriatric Cognitive Disorders·A McCaddonC Wilkinson
Nov 27, 2002·The American Journal of Psychiatry·Henning TiemeierMonique M B Breteler
Jan 22, 2003·Drugs & Aging·Imrich Blasko, Beatrix Grubeck-Loebenstein
Aug 21, 2003·The Journal of Neuropsychiatry and Clinical Neurosciences·Martin SteinbergConstantine G Lyketsos
Apr 6, 2004·International Journal of Geriatric Psychiatry·Sebastiaan EngelborghsPeter P De Deyn
Jun 24, 2004·The American Journal of Clinical Nutrition·Pierluigi QuadriUgo Lucca
Jul 16, 2004·International Journal of Geriatric Psychiatry·Karin NilssonBjörn Hultberg
Dec 2, 2004·Brain Research. Brain Research Reviews·Rodrigo A FuentealbaNibaldo C Inestrosa
Apr 13, 2005·International Journal of Cardiology·Lorenzo FácilaFco J Chorro
Apr 29, 2005·Psychological Medicine·Perminder S SachdevAnthony F Jorm
Aug 2, 2005·Progress in Neuro-psychopharmacology & Biological Psychiatry·Andreas ReifKlaus-Peter Lesch
Aug 5, 2005·European Journal of Cardiovascular Prevention and Rehabilitation : Official Journal of the European Society of Cardiology, Working Groups on Epidemiology & Prevention and Cardiac Rehabilitation and Exercise Physiology·Jyrki K VirtanenJukka T Salonen
May 11, 2007·Journal of Affective Disorders·Yamima OsherR H Belmaker
Feb 22, 2008·Current Alzheimer Research·Manuel Fernández-MartínezRafael Ortega
Apr 24, 2008·The Journal of Nutritional Biochemistry·Hyun-Jung KimYoung Hye Kwon
Jul 16, 2008·Archives of Neurology·Sid E O'BryantJohn A Lucas
Nov 5, 2008·Archives of General Psychiatry·Osvaldo P AlmeidaLeon Flicker
Jun 2, 2009·International Journal of Geriatric Psychiatry·Abderrahim OulhajA David Smith
Jul 3, 2009·International Journal of Clinical Practice·T VogelE Andrès
Sep 3, 2010·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Cheng-Sheng ChenYi-Cheng Liao
Feb 18, 2011·The Cochrane Database of Systematic Reviews·Dallas P SeitzPaula Rochon
Oct 23, 2014·Neuropsychiatric Disease and Treatment·Hyun Kim, Kang Joon Lee
Mar 4, 2015·BMJ : British Medical Journal·Helen C KalesConstantine G Lyketsos

❮ Previous
Next ❯

Citations

Jan 23, 2021·International Journal of Molecular Sciences·Hendrik NieraadGerd Geisslinger
Jun 9, 2021·Proceedings of the National Academy of Sciences of the United States of America·Dorin Sade YazdiEhud Gazit
Jun 15, 2021·Frontiers in Aging Neuroscience·Qianwen WangRuixia Zhu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.