Serum Homocysteine and Cysteine Levels and Anthropometric Changes: A Longitudinal Study among Brazilian Children and Adolescents

Journal of the American College of Nutrition
Priscila R F CostaAna Marlúcia Oliveira Assis

Abstract

This article aimed to identify the influence of high serum homocysteine (Hcy) and cysteine (Cys) levels, alone or in conjunction, on changes in anthropometric parameters in children and adolescents over a 12-month follow-up period. This is a cohort study involving 483 boys and girls 7-15 years of age. The outcome variables were body mass index (BMI)-for-age and waist circumference (WC) and the principal exposure variables were serum Hcy and Cys levels, alone or in conjunction. A generalized estimating equation (GEE) approach was used to identify longitudinal changes in the outcome variables. Irrespective of age, sex, socioeconomic conditions, dietary intake, or the practice of physical activity, the children and adolescents in the fifth quintile of distribution of Hcy levels had a z-score increase of 0.50 (p < 0.01) and a 3.62 cm increase (p < 0.01) in mean BMI-for-age and WC, respectively, over the period of the study. In individuals with Cys values above the fifth quintile, a z-score increase of 0.59 (p < 0.01) and a 5 cm increase (p < 0.01) were found in BMI-for-age and WC, respectively. When serum Hcy and Cys levels were both above the fifth quintile of distribution, a z-score increase of 0.87 (p < 0.01) and a 6.57 cm incre...Continue Reading

References

Dec 14, 2005·European Journal of Pediatrics·Weihua ZhuHenning Neubauer
Apr 22, 2006·Arquivos brasileiros de endocrinologia e metabologia·Roberto Fernandes da CostaMauro Fisberg
Nov 16, 2007·Acta Paediatrica·D PapandreouI Mavromichalis
Nov 21, 2007·Bulletin of the World Health Organization·Mercedes de OnisJonathan Siekmann
May 10, 2011·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·A K ElshorbagyH Refsum
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Dec 7, 2014·Revista paulista de pediatria : orgão oficial da Sociedade de Pediatria de São Paulo·Elyssia Karine Nunes Mendonça RamiresLeiko Asakura

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Citations

Dec 23, 2020·Nutrition Reviews·Luana de Oliveira LeitePriscila Ribas de Farias Costa

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