Serum homocysteine, folate, and vitamin B12 levels in patients with vitiligo and their potential roles as disease activity biomarkers: A systematic review and meta-analysis

Journal of the American Academy of Dermatology
Tsung-Yu TsaiYu-Chen Huang

Abstract

Hyperhomocysteinemia and folate and vitamin B12 deficiencies have been reported in patients with vitiligo. Investigating the role of these conditions might shed light on the pathogenesis of vitiligo. To perform a systematic review and meta-analysis of studies assessing serum homocysteine, folate, and vitamin B12 levels in vitiligo patients. Online databases were searched on May 15, 2018, to identify studies comparing serum homocysteine, folate, and vitamin B12 levels between patients with vitiligo and controls. A random effects model was used. Twenty-two studies involving a total of 1448 patients with vitiligo were included. Patients with vitiligo had significantly higher serum homocysteine levels (standardized mean difference [SMD] 0.550, 95% confidence interval [CI] 0.262-0.838; I2 87.3%) and lower vitamin B12 levels (SMD -0.430, 95% CI -0.738 to -0.121; I2 85.3%) than controls. Serum folate levels were not significantly different between the 2 groups (SMD -0.240, 95% CI -0.592 to 0.111; I2 85.5%). A subgroup analysis revealed that these findings correlated with disease activity. The included studies were heterogeneous. Serum homocysteine levels could be influenced by various factors. Patients with vitiligo have higher serum ...Continue Reading

Citations

Feb 6, 2020·Dermatologic Therapy·Ayman AbdelmaksoudMrinal Gupta
Oct 1, 2020·Food Science & Nutrition·Tahniat RehmanRana Muhammad Aadil
Feb 18, 2020·International Journal of Immunogenetics·Arash Bagheri HamidiJouni Uitto
Oct 24, 2020·Scientific Reports·Wei LiuDong-Lai Ma
Jul 21, 2021·Clinical Reviews in Allergy & Immunology·Yinghan WangChunying Li

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