Serum homocysteine, folate level and methylenetetrahydrofolate reductase 677, 1298 gene polymorphism in Korean schizophrenic patients

Neuroreport
Young Sik LeeSoo Churl Cho

Abstract

High homocysteine serum level has been regarded as one of the important factors that influence the development of schizophrenia. Genetic variations of methylenetetrahydrofolate reductase, which is a main enzyme reducing homocysteine level, are reported in schizophrenic patients. We measured the serum level of homocysteine/folate and methylenetetrahydrofolate reductase C677T/A1298C gene polymorphism in 235 patients with schizophrenia. Plasma homocysteine levels were higher and folate levels were lower in patients than in comparison subjects. Variations of C677T were more frequent in patients than in comparison subjects. Patients with the 677TT genotype showed higher homocysteine levels than patients with the CC and CT genotypes. These findings suggest that folate supplement may be beneficial to some schizophrenic patients with homocysteinemia due to the genetic defect of methylenetetrahydrofolate reductase.

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Citations

Jul 23, 2013·Neurochemical Research·Adam Wysokiński, Iwona Kłoszewska
Jul 25, 2009·The Australian and New Zealand Journal of Psychiatry·Yin Ying MaTing Keung Poon
Dec 17, 2008·Pharmacogenomics·Hamid Mostafavi AbdolmalekyCassandra L Smith
Aug 10, 2007·Harvard Review of Psychiatry·Frances Rachel Frankenburg
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May 24, 2020·Psychiatry and Clinical Neurosciences·Yukiko TomiokaTetsuro Ohmori
Jun 10, 2020·European Archives of Psychiatry and Clinical Neuroscience·Yating YangHuanzhong Liu

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