Serum Homocysteine Levels in Men with and without Erectile Dysfunction: A Systematic Review and Meta-Analysis

International Journal of Endocrinology
Andrea SansoneAndrea Lenzi

Abstract

Elevated levels of serum homocysteine (Hcy) have been associated with cardiovascular diseases and endothelial dysfunction, conditions closely associated with erectile dysfunction (ED). This meta-analysis was aimed to assess serum Hcy levels in subjects with ED compared to controls in order to clarify the role of Hcy in the pathogenesis of ED. Medline, Embase, and the Cochrane Library were searched for publications investigating the possible association between ED and Hcy. Results were restricted by language, but no time restriction was applied. Standardized mean difference (SMD) was obtained by random effect models. A total of 9 studies were included in the analysis with a total of 1320 subjects (489 subjects with ED; 831 subjects without ED). Pooled estimate was in favor of increased Hcy in subjects with ED with a SMD of 1.00, 95% CI 0.65-1.35, p < 0.0001. Subgroup analysis based on prevalence of diabetes showed significantly higher SMD in subjects without diabetes (1.34 (95% CI 1.08-1.60)) compared to subjects with diabetes (0.68 (95% CI 0.39-0.97), p < 0.0025 versus subgroup w/o diabetes). Results from our meta-analysis suggest that increased levels of serum Hcy are more often observed in subjects with ED; however, increase ...Continue Reading

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Citations

Dec 14, 2018·International Urology and Nephrology·Attia Abd Allah AttiaSameh Fayek GamalEl Din
Jul 15, 2020·Journal of Endocrinological Investigation·A SansoneE A Jannini
Nov 4, 2020·Andrologia·Abhimanyu GuptaPrafulla Kumar Swain
Jan 7, 2021·International Journal of Molecular Sciences·Gianmaria SalvioGiancarlo Balercia
Jan 9, 2022·Journal of Endocrinological Investigation·A SansoneE A Jannini

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