Serum homocysteine, vitamin B 12 and folic acid levels in different types of glaucoma

BMC Ophthalmology
Tongabay CumurcuErdinc Aydin

Abstract

This study was performed to compare levels of serum homocysteine (Hcy), vitamin B12 and folic acid in patients with primary open-angle glaucoma (POAG), pseudoexfoliative glaucoma (PEXG), normotensive glaucoma (NTG) and healthy controls. Twenty-five patients with POAG, 24 with PEXG, and 18 with NTG, along with 19 control healthy subjects were included this prospective study. Levels of serum Hcy were measured using immunoassay, and those of serum vitamin B12 and folic acid were measured using competitive chemiluminescent enzyme immunoassay. The mean Hcy concentration in the PEXG group was significantly higher (P < 0.001) as compared to the other groups. There were no significant differences with respect to the mean Hcy concentrations among other groups (P > 0.05). There were no statistical differences in serum vitamin B12 levels among POAG, PEXG, NTG and control subjects (P > 0.05). The mean serum folic acid level was significantly lower in the subjects with PEXG (P < 0.009). However, the mean folic acid concentrations among the other groups did not differ significantly (P > 0.05). Elevated levels of Hcy in PEXG may explain the role of endothelial dysfunction among patients with PEXG.

References

Aug 19, 1992·JAMA : the Journal of the American Medical Association·M J StampferC H Hennekens
Jun 1, 1987·Acta Ophthalmologica·K KarjalainenL Merenmies
Aug 1, 1997·American Journal of Ophthalmology·V BiousseP Sternberg
Dec 31, 1997·American Journal of Ophthalmology·P MitchellW Smith
May 20, 1998·European Journal of Pediatrics·J D Finkelstein
Aug 7, 1999·Lancet·G J Hankey, J W Eikelboom
Feb 3, 2000·The British Journal of Ophthalmology·M CahillI Graham
Aug 25, 2000·Journal of Vascular Surgery·T BrunelliG Pepe
Feb 15, 2001·Current Opinion in Neurology·G J Hankey, J W Eikelboom
Feb 24, 2001·Lancet·S SchumacherG O Naumann
Jul 19, 2001·Journal of Neural Transmission·F LeblhuberD Fuchs
Jul 27, 2001·Progress in Retinal and Eye Research·S S Hayreh
Feb 5, 2002·Ophthalmology·Bruce A BrownAllen B Thach
Aug 2, 2002·Progress in Retinal and Eye Research·Josef FlammerEinar Stefánsson
Dec 18, 2002·Journal of Neural Transmission·S BleichJ Kornhuber
Feb 5, 2003·Journal of Glaucoma·Igal LeibovitchAnat Loewenstein
Jul 2, 2003·American Journal of Ophthalmology·Roberto M VessaniMark Jofe
Dec 4, 2003·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·A A WarsiM H Lewis
Mar 12, 2004·American Journal of Ophthalmology·Gloria WangRobert N Weinreb
Mar 20, 2004·The British Journal of Ophthalmology·G G KoliakosN Georgiadis
Mar 31, 2004·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tuomo PuustjärviMarkku Teräsvirta
Feb 3, 2005·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Ozgül AltintaşYusuf Cağlar

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Citations

Aug 10, 2011·Archives of Ophthalmology·Joshua D SteinJulia E Richards
Aug 27, 2010·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Laura TranchinaGianluca Manni
Dec 3, 2011·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Fan XuMin Li
Aug 26, 2006·Journal of Neural Transmission·J B RoedlA G M Jünemann
Dec 1, 2007·Chemical Communications : Chem Comm·Werner TjarksRolf F Barth
Nov 23, 2011·Academic Medicine : Journal of the Association of American Medical Colleges·Igor J Polianski, Heiner Fangerau
Jan 15, 2009·Journal of Glaucoma·Colin I ClementStuart L Graham
Feb 25, 2010·Journal of Glaucoma·Christopher W RösslerAnselm G M Juenemann
Mar 31, 2012·Current Eye Research·Asaad A GhanemLamiaa F Arafa
May 15, 2013·Seminars in Ophthalmology·Tongabay CumurcuErcan Ozsoy
Jan 14, 2017·Eye·C C CousinsL R Pasquale
Mar 17, 2017·International Ophthalmology·Prakadeeswari GopalakrishnanPeriasamy Sundaresan
Mar 17, 2018·Nutrients·Wishal D RamdasCarroll A B Webers
Jul 1, 2008·Indian Journal of Clinical Biochemistry : IJCB·S K SenRebecca Abraham
Mar 10, 2020·Molecular Omics·Ciara MyerSanjoy K Bhattacharya
Aug 1, 2014·International Ophthalmology·N López-RiquelmeF Hernández
Feb 23, 2008·Current Eye Research·Tongabay CumurcuHuseyin Yardim
Oct 22, 2020·Nutrients·Annagrazia AdornettoRossella Russo
Jul 30, 2020·Canadian Journal of Physiology and Pharmacology·Akash K GeorgeMahavir Singh

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Humphrey Field Analyzer
SPSS

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