PMID: 2108492Jan 1, 1990Paper

Serum hormone levels in men with end stage renal disease

Scandinavian Journal of Urology and Nephrology
K CarlströmA Lindholm

Abstract

Serum concentrations of testicular and adrenal androgens and androgen precursors, cortisol, unconjugated (E1) and total estrone (tE1; greater than or equal to 85% E1 sulfate), pituitary hormones, sex hormone binding globulin (SHBG) and albumin were measured in 14 male patients with non-diabetic end stage renal disease and in 28 age-matched healthy controls. The serum levels of the adrenal androgens 4-androstene 3,17-dione and dehydroepiandrosterone (DHA) were significantly lower and the levels of cortisol, LH, prolactin and tE1 significantly higher in the patients than in the controls. The ratios between E1 and tE1 and between DHA and DHA sulfate were strongly decreased in the patients. The findings are suggested to reflect different effects of the disease upon the metabolism of cortisol and of adrenal androgens and also the reduced or even absent urinary excretion, leading to a decreased metabolism of steroid conjugates.

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Citations

Feb 1, 1992·Acta Anaesthesiologica Scandinavica·A LindhN Wilking
Mar 7, 2014·The Journal of Endocrinology·Tracey A QuinnDavid W Walker
Nov 28, 2013·Endocrine·Giacomo TirabassiGiorgio Arnaldi
Jan 2, 2010·Growth Hormone & IGF Research : Official Journal of the Growth Hormone Research Society and the International IGF Research Society·Per IvarsenJan Frystyk
Mar 27, 2004·Clinical Chemistry·K C Allen ChanChristopher W K Lam
Nov 7, 1998·Archives of Andrology·I SasagawaH Miura
Aug 26, 2000·The Journal of Nutrition·S JayapalanH M Aukema

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