Serum Human Chorionic Gonadotropin Normogram for the Detection of Gestational Trophoblastic Neoplasia

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Yalcke EysboutsAntonius van Herwaarden

Abstract

The aim of this study was to develop a serum human chorionic gonadotropin (hCG) normogram for both uneventful complete and partial hydatidiform moles in the first-trimester ultrasound era. An hCG normogram for both complete and partial hydatidiform moles was constructed, based on 639 patients with uneventful serum hCG regression after evacuation between 1990 and 2014. Serum hCG was measured by an in-house-developed radioimmunoassay, detecting both intact hCG and free β-subunit. It has been in use for all serum measurements sent to the Dutch Central Registry for Hydatidiform Moles since 1977. Since introduction of routine first-trimester ultrasonography, lower pre-evacuation and follow-up serum hCG concentrations were observed. When compared with complete hydatidiform moles, patients with a partial hydatidiform mole had significantly lower pre-evacuation serum hCG concentration (median, 4400 and 875 ng/mL, respectively; P < 0.001) and earlier hCG normalization (median, 7 and 6 weeks, respectively; P < 0.001) but higher gestational age (mean, 11.5 and 13.0 weeks, respectively; P < 0.001). For both complete and partial hydatidiform moles, 95% of patients reached normal serum hCG concentrations within 14 weeks after evacuation. A n...Continue Reading

References

Mar 1, 1988·The Journal of Clinical Endocrinology and Metabolism·D L Hay
Nov 1, 1995·Obstetrics and Gynecology·V Soto-WrightR S Berkowitz
Jan 1, 1997·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·E Jauniaux, K H Nicolaides
Oct 21, 2000·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·J L BenedetS Pecorelli
Jun 18, 2002·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·UNKNOWN FIGO Oncology Committee
Sep 16, 2003·Clinical Obstetrics and Gynecology·Rex C Bentley
Feb 7, 2004·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·H Y NganUNKNOWN FIGO Committee on Gynecologic Oncology
Jan 22, 2009·Obstetrics and Gynecology·Linda G W KerkmeijerChris M G Thomas
Apr 17, 2009·The New England Journal of Medicine·Ross S Berkowitz, Donald P Goldstein
Aug 3, 2010·Lancet·Michael J SecklRoss S Berkowitz
Feb 5, 2011·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Brigitte M RonnettKathleen M Murphy
Sep 4, 2013·Annals of Oncology : Official Journal of the European Society for Medical Oncology·M J SecklUNKNOWN ESMO Guidelines Working Group
Feb 18, 2014·Current Obstetrics and Gynecology Reports·Ngoc Minh Phuong Nguyen, Rima Slim

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Citations

Nov 30, 2019·Biometrical Journal. Biometrische Zeitschrift·Rana DandisJoanna IntHout
Sep 14, 2020·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Murali SubbaiahAnish Keepanasseril
Jan 11, 2021·Best Practice & Research. Clinical Obstetrics & Gynaecology·Christianne LokNienke van Trommel

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