Serum human epididymis protein 4 is associated with the treatment response of concurrent chemoradiotherapy and prognosis in patients with locally advanced non-small cell lung cancer

Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico
W-G LanL-B Ma

Abstract

To investigate the role of human epididymis protein 4 (HE4) in the diagnosis and prognosis of patients with locally advanced non-small cell lung cancer (LA-NSCLC) receiving concurrent chemoradiotherapy (CRT). A total of 218 patients with LA-NSCLC were enrolled. All patients underwent CRT. The treatment response to CRT was evaluated. The prognosis analysis was performed using relapse-free survival (RFS) and overall survival [1]. Our data show that the serum HE4 can discriminate patients who respond well to CRT from those who respond poorly. Higher serum HE4 had dramatically increased risk of being non-responders to CRT. Serum HE4 level is also associated with prognosis of patients after CRT. Patients with high HE4 level had shorter RFS and OS compared to those with low HE4 level. Our data suggest that serum HE4 may be a useful prognostic biomarker for LA-NSCLC patients who underwent CRT.

References

Oct 25, 2012·Clinical Chemistry and Laboratory Medicine : CCLM·Linda HertleinAlexander Burges
Sep 13, 2013·The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease·W LiuW-L Liu
Jul 24, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Ximing WangWenchao Liu
Jun 2, 2015·PloS One·Pierre-Jean LamyJean-Louis Pujol

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Citations

Jun 2, 2015·PloS One·Pierre-Jean LamyJean-Louis Pujol
Oct 25, 2017·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G YavasS Akyurek
May 3, 2019·Journal of Cellular Biochemistry·Youwei ZhangSanyuan Sun
Oct 11, 2016·Journal of Cancer Prevention·Ho Il YoonChul Woo Kim

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