Serum human glandular kallikrein 2 (hK2) for distinguishing stage and grade of prostate cancer

International Journal of Urology : Official Journal of the Japanese Urological Association
Carsten StephanE P Diamandis

Abstract

Human glandular kallikrein (hK2) has been shown to add important information regarding the early detection and staging of prostate cancer. Preliminary analysis pointed out that hK2 may discriminate between pT2 and pT3 tumors, and that hK2 may predict Gleason grade 4/5 cancer volume, better than prostate-specific antigen (PSA) or percent free PSA (%fPSA). We investigated the role of hK2 serum values for predicting pathological stage, grade and Gleason score. Prostate-specific antigen, free PSA and hK2 were measured on 222 untreated prostate cancer patients who had received radical prostatectomy at the Charité Hospital, Berlin, Germany. Pathological work up revealed pT2-cancer in 111 patients and pT3-cancer in 111 patients. Grade 2 was found in 118 patients whereas grade 3 tumors were found in 104 patients. For pT2 and pT3 patients, the %fPSA (P=0.006), the ratios hK2/fPSA (P=0.08) and hK2xtPSA/fPSA (P=0.002) were all significant different whereas hK2 (P=0.143) and PSA (P=0.1) did not differ. Between grade 2 and grade 3 tumors, the hK2 alone (P=0.27), the %fPSA (P=0.13), the ratios hK2/fPSA (P=0.94) and hK2xtPSA/fPSA (P=0.12) did not separate, whereas PSA (P=0.039) showed a difference. The same relationships were found between th...Continue Reading

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Citations

Feb 12, 2010·Future Oncology·Konstantinos Mavridis, Andreas Scorilas
Oct 19, 2012·Biomarkers in Medicine·Girish Sardana, Eleftherios P Diamandis
Jan 31, 2012·Pathology, Research and Practice·Constantina PetrakiGeorge M Yousef
Oct 16, 2007·The Journal of Urology·Dipen J ParekhIan M Thompson
Aug 11, 2007·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Carsten StephanEleftherios P Diamandis
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Anja RabienCarsten Stephan
Mar 18, 2016·EJNMMI Research·O Vilhelmsson TimmermandSe Strand
Apr 15, 2014·Biochimica Et Biophysica Acta·Carsten StephanKlaus Jung
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Jan 13, 2015·Clinical Chemistry and Laboratory Medicine : CCLM·Xavier Filella, Laura Foj

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