Serum hyaluronic acid in patients with veno-occlusive disease following bone marrow transplantation

Bone Marrow Transplantation
M W FriedGeorge B McDonald

Abstract

The development of hepatic veno-occlusive disease following bone marrow transplantation is associated with high-dose combination cytoreductive therapy. Experimental models have suggested that drug-induced injury to hepatic sinusoidal endothelial cells is involved in the pathogenesis of this syndrome. Hyaluronic acid is a polysaccharide that is metabolized, almost exclusively, by hepatic sinusoidal endothelial cells. The aim of the present study was to evaluate serum hyaluronic acid as a marker for endothelial cell injury in patients with veno-occlusive disease following bone marrow transplantation. Hyaluronic acid was measured in sera from patients with and without veno-occlusive disease using an enzyme-linked protein binding assay. Mean peak serum hyaluronic acid levels were significantly greater in patients who had a diagnosis of VOD compared to those transplant patients who did not, 1173.4 +/- 982.9 vs 444.9 +/- 735.6 ng/ml (P = 0.01). Serial serum samples obtained from a separate cohort of patients also demonstrated that serum hyaluronic acid levels were higher in patients with moderate or severe veno-occlusive disease compared to those with none or mild disease at days 7, 17 and 25 following transplantation (greatest diffe...Continue Reading

References

Mar 1, 1989·Transplantation·D H AdamsJ M Neuberger
Jan 1, 1988·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A NybergL Lööf
Jan 1, 1984·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·G B McDonaldE D Thomas
Mar 1, 1983·Experimental Cell Research·S ErikssonB Smedsrød
May 1, 1994·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H M ShulmanG B McDonald
Sep 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·M W FriedT D Boyer
Jun 1, 1996·Annals of Medicine·T C LaurentJ R Fraser
Oct 1, 1996·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·L D DeLeve

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Citations

Mar 19, 2003·Blood Reviews·Jason A CoppellDavid J Perry
Jun 14, 2003·Journal of Hematotherapy & Stem Cell Research·John GerecitanoDavid L Porter
Apr 12, 2003·Leukemia & Lymphoma·Kohji YoshimotoMichio Sata
Sep 24, 2011·Seminars in Radiation Oncology·Chandan Guha, Brian D Kavanagh
Jan 11, 2013·Journal of Zhejiang University. Science. B·Xia-zhen YuTing-bo Liang
Jan 31, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Paul L MartinJoanne Kurtzberg
Jan 19, 2008·Expert Reviews in Molecular Medicine·Lorne A Clarke
Sep 30, 2016·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Magali GuffroyNasir Khan
Sep 12, 2018·Chemical Reviews·Nikos K KaramanosRenato V Iozzo

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