PMID: 15222397Jun 30, 2004Paper

Serum IgE elevation correlates with blood lead levels in battery manufacturing workers

Human & Experimental Toxicology
Y HeoDavid A Lawrence

Abstract

Lead (Pb), an occupational and environmental toxicant, is known to induce immunomodulatory effects resulting in lowered resistance to infectious micro-organisms and altered levels of immunoglobulins in humans. Preferential activation of type-2 helper T cells and inhibition of type-1 T-cell activation is considered a cellular mechanism for the Pb-induced immune alteration, which has not been investigated well in humans. Lead's influence on in vivo balance between type-1 and type-2 activities was assessed among workers exposed to Pb through battery manufacturing in Korea. Serum IgE levels were significantly higher in the workers with a blood Pb level (PbB) of > or = 30 microg/dL than in the workers with a PbB of < 30 microg/dL. Furthermore, the serum IgE concentrations significantly correlated with PbB although no significant relationship between PbB and serum interleukin-4 or interferon gamma levels was observed. The present study indicates that elevation of IgE levels may be an immunologic index for Pb-induced in vivo toxicities, potentially involved with progression of various allergic diseases in humans.

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Citations

Jul 29, 2011·Journal of Occupational and Environmental Hygiene·Perry Gottesfeld, Amod K Pokhrel
Apr 16, 2005·Environmental Health : a Global Access Science Source·Wilfried KarmausHermann Kruse
Jul 5, 2005·Toxicology and Applied Pharmacology·Michael A LynesK Michael Pollard
Jul 6, 2011·Journal of Immunotoxicology·Chu-Lin HsiaoKong-Sang Wan
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Kyoung-Bok Min, Jin-Young Min
Jul 9, 2016·Journal of Immunotoxicology·Michał DobrakowskiSławomir Kasperczyk
Apr 13, 2017·Journal of Exposure Science & Environmental Epidemiology·I-Jen WangChen-Chang Yang
Apr 28, 2017·Toxicology Mechanisms and Methods·Stephen J Genuis, Edmond Kyrillos
Dec 8, 2017·Critical Reviews in Clinical Laboratory Sciences·Prasenjit MitraPraveen Sharma
Mar 17, 2016·American Journal of Rhinology & Allergy·Jeong Hong KimJu Wan Kang
Apr 22, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nasr Y A HemdanUlrich Sack
Jul 1, 2006·Critical Reviews in Toxicology·Rodney R Dietert, Michael S Piepenbrink
Jun 23, 2019·Biological Trace Element Research·Zhenzhen PanLing Li
Mar 11, 2021·Archives of Environmental & Occupational Health·Jianrui DouFeng Zhang

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