Serum IgE, tumor epidermal growth factor receptor expression, and inherited polymorphisms associated with glioma survival

Cancer Research
Margaret WrenschMichael Prados

Abstract

In population-based glioma patients, we examined survival in relation to potentially pertinent constitutive polymorphisms, serologic factors, and tumor genetic and protein alterations in epidermal growth factor receptor (EGFR), MDM2, and TP53. Subjects were newly diagnosed adults residing in the San Francisco Bay Surveillance Epidemiology and End Results Area during 1991 to 1994 and 1997 to 1999 with central neuropathology review (n = 873). Subjects provided blood for serologic studies of IgE and IgG to four herpes viruses and constitutive specimens for genotyping 22 polymorphisms in 13 genes (n = 471). We obtained 595 of 697 astrocytic tumors for marker studies. We determined treatments, vital status, and other factors using registry, interview, medical record, and active follow-up data. Cox regressions for survival were adjusted for age, gender, ethnicity, study series, resection versus biopsy only, radiation, and chemotherapy. Using a stringent P < 0.001, glioma survival was associated with ERCC1 C8092A [hazard ratio (HR), 0.72; 95% confidence limits (95% CL), 0.60-0.86; P = 0.0004] and GSTT1 deletion (HR, 1.64; 95% CL, 1.25-2.16; P = 0.0004); glioblastoma patients with elevated IgE had 9 months longer survival than those wi...Continue Reading

References

Jan 1, 1994·Advances in Experimental Medicine and Biology·D H ConradS E Dierks
Jul 1, 1993·Brain Pathology·P KleihuesB W Scheithauer
Mar 1, 1996·International Journal of Radiation Biology·D MurrayE Rosenberg
May 1, 1997·Biochemical Society Transactions·D H ConradS Cho
Aug 16, 2001·Journal of the National Cancer Institute·J S SmithR B Jenkins
Jul 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kimberly A RismaGurjit K Khurana Hershey
Sep 13, 2002·Immunology·Paul R WalkerPierre-Yves Dietrich
Oct 29, 2002·Diabetes·Daniel B MirelJanelle A Noble
Jan 15, 2003·Annual Review of Medicine·R NagasubramanianM J Ratain
Mar 28, 2003·Cancer Genetics and Cytogenetics·Yuichi HiroseBurt G Feuerstein
Jan 22, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tracy T BatchelorDavid N Louis
Apr 23, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·M Fatih OkcuMelissa Bondy
Apr 24, 2004·Cancer Letters·Alexandre Loktionov
Jul 23, 2004·The Journal of Molecular Diagnostics : JMD·Rodney N WiltshireRoger E McLendon
Jul 29, 2004·Neuro-oncology·Kathleen R LambornMichael D Prados
Aug 7, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei ZhouDavid C Christiani
Sep 18, 2004·Cancer Research·William A FreijeStanley F Nelson
Oct 7, 2004·Cancer Research·Hiroko OhgakiPaul Kleihues
Nov 16, 2004·Current Opinion in Neurology·M J van den Bent
Nov 19, 2004·Cancer Research·Joseph L WiemelsMargaret Wrensch
Dec 24, 2004·American Journal of Epidemiology·Simone Benhamou, Alain Sarasin
Feb 22, 2005·Current Medicinal Chemistry. Anti-cancer Agents·Pascal Sève, Charles Dumontet
Mar 5, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Rebecca SukDavid C Christiani
May 19, 2005·Cancer Research·Jeremy N RichMike West
Jun 11, 2005·Neuroepidemiology·Katie L MillerMargaret Wrensch
Jun 23, 2005·Frontiers in Bioscience : a Journal and Virtual Library·Christopher J Wheeler, Keith L Black
Jul 19, 2005·Cancer Research·Judith SchwartzbaumMaria Feychting
Jul 21, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·John K WienckeMargaret Wrensch
Aug 17, 2005·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Jianming TangCharles S Cobbs
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Eddie Reed
Sep 8, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jérôme ViguierFrançoise Praz
Oct 4, 2005·Neurological Research·Christian W Sikorski, Maciej S Lesniak
Oct 11, 2005·Neuro-oncology·Margaret WrenschJohn K Wiencke
Oct 14, 2005·Expert Review of Anticancer Therapy·S Farzana Hussain, Amy B Heimberger

❮ Previous
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Citations

Dec 6, 2011·Cancer Immunology, Immunotherapy : CII·Martin H Bluth
Dec 21, 2011·Cancer Immunology, Immunotherapy : CII·Michelle C Turner
May 10, 2007·Current Neurology and Neuroscience Reports·Jennifer M Connelly, Mark G Malkin
Aug 26, 2006·Nature Clinical Practice. Neurology·Judith A SchwartzbaumMargaret Wrensch
Aug 2, 2008·The New England Journal of Medicine·Patrick Y Wen, Santosh Kesari
Jul 12, 2011·American Journal of Epidemiology·Daniel H LachanceMargaret R Wrensch
Jul 30, 2010·Carcinogenesis·Judith A SchwartzbaumMargaret R Wrensch
Mar 4, 2010·Neuro-oncology·Sara SjöströmBeatrice Melin
Jan 12, 2012·Neuro-oncology·Jessica C Amlin-Van SchaickKarlyne M Reilly
Aug 21, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·C ChenS Wu
May 9, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Preetha RajaramanStephen J Chanock
Jul 5, 2011·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·E Susan AmirianMelissa L Bondy
Oct 18, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Michael E ScheurerMelissa L Bondy
May 18, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mitsugu FujitaHideho Okada
Apr 5, 2012·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuanyuan XiaoMargaret R Wrensch
Jun 17, 2009·BMC Evolutionary Biology·Tim DowningDaniel G Bradley
Jan 19, 2012·Journal of Neuroinflammation·Colleen S Curran, Paul J Bertics
Sep 8, 2011·International Journal of Medical Sciences·Antonis ValachisEvangelos G Papanikolau
Jan 1, 2010·Clinical & Developmental Immunology·Lisheng GeMartin R Jadus
Sep 6, 2014·Neuro-oncology·David A ReardonGlenn Dranoff
May 14, 2010·American Journal of Epidemiology·Minouk J SchoemakerAnthony J Swerdlow
Aug 15, 2014·Expert Review of Proteomics·Savita JayaramRavi Sirdeshmukh
Dec 15, 2012·Cancer Genetics·McKinsey L Goodenberger, Robert B Jenkins
Oct 4, 2011·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Kenji HiranoKazuhiko Koike
Feb 28, 2009·Autoimmunity Reviews·Catherine Nissen, Martin Stern
Dec 11, 2007·Cancer Genetics and Cytogenetics·Vítor Lima-RamosRui Manuel Reis
Oct 30, 2007·Neurologic Clinics·James L FisherJoseph L Wiemels
Sep 19, 2008·Cancer·Melissa L BondyUNKNOWN Brain Tumor Epidemiology Consortium
Feb 10, 2010·International Journal of Cancer. Journal International Du Cancer·Sara H OlsonRobert C Kurtz
May 9, 2013·Annals of the New York Academy of Sciences·Hideho OkadaMelissa L Bondy
Oct 18, 2013·Cancer Medicine·E Susan AmirianMichael E Scheurer
Oct 15, 2013·Biological Reviews of the Cambridge Philosophical Society·Elena S GusarevaMarie Lipoldová
Sep 17, 2011·Immunology Letters·Barbara PlatzerEdda Fiebiger
Feb 24, 2015·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Matthew N T ThuyKatharine J Drummond
Jan 5, 2011·Journal of Neuroimmunology·Bryan A BassigAlina V Brenner
Jan 2, 2015·Neurosurgical Focus·Elizabeth B ClausMargaret Wrensch
May 26, 2016·Cancer Immunology, Immunotherapy : CII·Thomas V GuyBarbara Fazekas de St. Groth
Sep 9, 2017·The International Journal of Biological Markers·Fadi S SaadehHazem I Assi
Jun 2, 2016·Radiology and Oncology·Tanja Mesti, Janja Ocvirk
May 2, 2009·International Journal of Cancer. Journal International Du Cancer·Joseph L WiemelsMargaret Wrensch

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