Serum IGFBP-2 levels are associated with reduced insulin sensitivity in obese children

Clinical Obesity
S W YauMatthew A Sabin

Abstract

Insulin-like growth factor binding protein 2 (IGFBP-2) may represent a critical link between body composition and insulin sensitivity. We investigated the relationship between circulating IGFBP-2 levels, body composition, insulin sensitivity, energy intake and physical activity in children with obesity. Children were recruited via the Weight Management Service at the Royal Children's Hospital, Melbourne, as part of the Childhood Overweight BioRepository of Australia (COBRA). Comprehensive anthropometric, biochemical and environmental data were collected and compared to serum IGFBP-2 levels (measured by enzyme-linked immunosorbent assay). Multiple regression modelling was used to assess the influence of circulating IGFBP-2 levels on anthropometric and biochemical measures. One hundred and ninety-four children were included in this study (46% male). Circulating IGFBP-2 negatively correlated with age, anthropometric measures, blood pressure and insulin concentration. Positive associations were observed between insulin sensitivity index-homeostasis model assessment (ISI-HOMA) and serum IGFBP-2. In multiple regression modelling, IGFBP-2 significantly contributes to variance in systolic blood pressure (-19%, P < 0.05), circulating tr...Continue Reading

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Citations

Dec 26, 2018·Arteriosclerosis, Thrombosis, and Vascular Biology·Ravi V ShahJane E Freedman
Jun 20, 2020·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Marc-André NolinFrédéric Picard
Jan 28, 2021·International Journal of Molecular Sciences·Hatim BoughanemManuel Macias-Gonzalez
Nov 19, 2020·Metabolites·Santiago Guerra-CanteraJulie A Chowen
Nov 6, 2018·Molecular Metabolism·Natalie J HaywoodStephen B Wheatcroft
Jan 19, 2022·Psychological Medicine·Marije van HaeringenRick Jansen

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