Serum IgG4 elevation in pancreatic cancer: diagnostic and prognostic significance and association with autoimmune pancreatitis

Pancreas
Taiwo NgwaSuresh T Chari

Abstract

Serum IgG4 (sIgG4) elevation, more common to autoimmune pancreatitis (AIP), occurs in some patients with pancreatic cancer (PaC). We investigated whether sIgG4 could differentiate AIP from PaC, its role in prognostication, and the concomitant occurrence of AIP and PaC. We identified all patients with PaC (n = 548) and with type 1 AIP (n = 99) with sIgG4 measurements from 2001 to 2011. We compared demographics and sIgG4 profiles in these groups. Among patients with PaC, we compared resectability and mortality with and without elevated sIgG4. We reviewed AIP and PaC tissue specimens to identify concomitant occurrence of both diseases. Patients with AIP were more likely to have elevation in sIgG4 (65% vs 10.4%, P < 0.001) and sIgG4 more than 2 times upper limit of normal (40% vs 2.4%, P < 0.001). Patients with PaC with sIgG4 elevation were more commonly male compared with those with normal sIgG4 (81% vs 53%). Both groups were similarly aged with similar rates of resectability and mortality. No evidence of concurrent PaC and AIP was found. Mild elevations in sIgG4 cannot distinguish AIP from PaC. Elevations more than 2 times upper limit of normal appear more commonly in AIP. Serum IgG4 elevation has no prognostic significance in Pa...Continue Reading

References

Feb 5, 1998·CA: a Cancer Journal for Clinicians·S H LandisP A Wingo
May 12, 1998·Surgical Oncology·A RikerD L Bartlett
Dec 28, 2002·The American Journal of Surgical Pathology·Susan C AbrahamRalph H Hruban
Jun 11, 2003·Annals of Surgery·Jeffrey M HardacreSteven D Leach
Dec 23, 2003·The American Journal of Gastroenterology·Terumi KamisawaNoriko Kamata
Jul 27, 2006·Pancreas·Hiromu InoueYukio Yoshida
Nov 24, 2006·The American Journal of Surgical Pathology·Vikram DeshpandeGregory Y Lauwers
Jun 9, 2007·The American Journal of Gastroenterology·Amaar GhazaleMichael B Farnell
Dec 20, 2007·Pancreas·Amaar Ghazale, Suresh Chari
Jan 10, 2008·Archives of Pathology & Laboratory Medicine·Amit RainaDavid C Whitcomb
Feb 2, 2008·Internal Medicine·Toshiro FukuiKazuichi Okazaki
May 5, 2009·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Suresh T ChariSanthi S Vege
Dec 3, 2010·Current Opinion in Rheumatology·Raghuwansh P Sah, Suresh T Chari
Mar 18, 2011·Pancreas·Tooru ShimosegawaUNKNOWN International Association of Pancreatology
Jan 16, 2013·The American Journal of Gastroenterology·Masahiro ShiokawaTsutomu Chiba
Jul 24, 2013·The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi·Hwan YoonSung Koo Lee
Jan 1, 2014·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kirsten BoonstraCyriel Y Ponsioen

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Citations

Jul 15, 2015·Current Opinion in Gastroenterology·Raghuwansh P Sah, Suresh T Chari
Sep 4, 2018·Scandinavian Journal of Gastroenterology·Min Liu, Mingju Hao
Sep 15, 2017·International Journal of Surgical Pathology·Kyle GearyGrace Guzman
Sep 7, 2018·Canadian Journal of Gastroenterology & Hepatology·Lumir KunovskyJan Trna
May 1, 2021·Journal of Clinical Medicine·Maria J Monroy-IglesiasAida Santaolalla
Apr 3, 2020·La Presse médicale·Vinciane Rebours, Philippe Lévy

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