Serum IL-17 and IL-23 levels and autoantigen-specific Th17 cells are elevated in patients with ANCA-associated vasculitis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Estela NogueiraAlan D Salama

Abstract

The Th17 subset has been implicated in the pathogenesis of a number of autoimmune diseases. However, little is known about its role in anti-neutrophil cytoplasm antibody (ANCA)-associated vasculitis (AAV). We measured serum levels of IL-17A and associated upstream cytokines and the frequency of IL-17-producing autoantigen-specific T cells in patients with AAV. ELISA on sera from acute (n = 28) and convalescent (n = 65) patients with AAV from Hammersmith Hospital was performed for IL-17A and the associated upstream cytokines IL-23, IL-6 and IL-1beta, as well as the Th1 cytokine IFN-gamma. ELISPOT was performed to measure autoantigen-specific recall T cell responses in convalescent patients and the frequency of IL-17- and IFN-gamma-producing cells. Serum IL-17A and IL-23 levels were significantly elevated in acute AAV patients compared to healthy controls (P < 0.01 and P < 0.001, respectively), but importantly, remained elevated in a proportion of convalescent patients. By contrast, no significant differences in IFN-gamma levels were detected between patient groups and controls. Patients with elevated levels of IL-23 compared to those with low IL-23 had more active disease as measured by Birmingham Vasculitis Activity Score (P < ...Continue Reading

References

Dec 1, 1994·QJM : Monthly Journal of the Association of Physicians·J W Paulley
Feb 1, 1994·Arthritis and Rheumatism·J C JennetteC G Kallenberg
Feb 1, 1996·Clinical and Experimental Immunology·M E GriffithC D Pusey
Jun 1, 1996·The Journal of Experimental Medicine·F FossiezS Lebecque
Aug 11, 1998·Journal of the American Society of Nephrology : JASN·C Van KootenM R Daha
Mar 12, 1999·Journal of the American Society of Nephrology : JASN·M A CunninghamS R Holdsworth
May 21, 1999·Multiple Sclerosis : Clinical and Laboratory Research·D MatuseviciusH Link
Jun 12, 1999·Annals of the Rheumatic Diseases·A C Muller KoboldJ W Tervaert
Nov 18, 2000·Arthritis and Rheumatism·K KurasawaI Iwamoto
Apr 8, 2003·Scandinavian Journal of Gastroenterology·O H NielsenB Vainer
Apr 12, 2003·Critical Care Medicine·Mitchell M LevyUNKNOWN SCCM/ESICM/ACCP/ATS/SIS
Nov 25, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Susumu NakaeYoichiro Iwakura
Apr 17, 2004·Kidney International·Wilhelm H SchmittUNKNOWN European Vasculitis Study Group
Mar 29, 2006·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Smaragdi MarinakiBenito A Yard
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yutaka KomiyamaYoichiro Iwakura
Jul 14, 2006·Kidney International·W H AbdulahadC G M Kallenberg
May 29, 2007·Arthritis and Rheumatism·Wayel H AbdulahadCees G M Kallenberg
Aug 7, 2007·Nature Immunology·Nicholas J WilsonRene de Waal Malefyt
Jun 26, 2008·Arthritis and Rheumatism·Wayel H AbdulahadCees G M Kallenberg
Aug 8, 2008·Proceedings of the National Academy of Sciences of the United States of America·Jonathan M CoquetDale I Godfrey
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gretta L StriteskyMark H Kaplan
Oct 23, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Chuanwang SongZuo-Hua Feng
Nov 5, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Guangpu ShiIgal Gery
Apr 3, 2009·Journal of the American Society of Nephrology : JASN·Hans-Joachim PaustUlf Panzer
Apr 10, 2009·Journal of the American Society of Nephrology : JASN·Joshua D OoiA Richard Kitching

❮ Previous
Next ❯

Citations

Aug 29, 2012·Current Rheumatology Reports·Rodrigo Cartin-CebaUlrich Specks
Feb 22, 2011·Clinical Reviews in Allergy & Immunology·Cees G M Kallenberg
Mar 8, 2011·Clinical Reviews in Allergy & Immunology·Wojciech SzczeklikJacek Musiał
Aug 14, 2013·Nature Reviews. Nephrology·Ton J Rabelink, Melissa H Little
Oct 7, 2010·Nature Reviews. Rheumatology·Min Chen, Cees G M Kallenberg
Nov 18, 2011·Current Opinion in Rheumatology·Mirjan M van Timmeren, Peter Heeringa
Nov 18, 2011·Current Opinion in Rheumatology·Alan D Salama, Mark A Little
Mar 23, 2011·Current Opinion in Nephrology and Hypertension·J Charles JennetteAdil H Gasim
Oct 27, 2010·Current Opinion in Hematology·Neil Basu, Lars-Peter Erwig
Jul 24, 2010·Nephrology·Joshua D OoiStephen R Holdsworth
Nov 14, 2012·American Journal of Nephrology·Yang-Gyun KimYeong-Hoon Kim
Mar 5, 2011·Arthritis Research & Therapy·Peter Heeringa, Mark A Little
Sep 6, 2011·Arthritis Research & Therapy·Wayel H AbdulahadCees G M Kallenberg
Oct 20, 2012·Arthritis Research & Therapy·Benjamin WildeJan Willem Cohen Tervaert
Jun 29, 2013·Autoimmunity Reviews·Franco DammaccoVito Racanelli
Apr 18, 2013·Annals of the Rheumatic Diseases·C A HusmannS Wieczorek
Jan 26, 2013·Annual Review of Pathology·J Charles JennetteHong Xiao
Sep 30, 2010·Current Rheumatology Reports·Cees G M Kallenberg
Oct 24, 2015·Journal of Autoimmunity·Amr H Sawalha, Mikhail G Dozmorov
Jul 6, 2013·Dermatologic Clinics·William Abramovits, Marcial Oquendo
Jun 15, 2013·Paediatric Respiratory Reviews·Henry J Rozycki, Wei Zhao
Apr 9, 2010·Kidney International·Jan-Eric TurnerUlf Panzer
Oct 7, 2011·Kidney International·Jana PindjakovaMatthew D Griffin
Dec 15, 2010·Kidney International·Benjamin WildeJan Willem Cohen Tervaert
Aug 16, 2011·Seminars in Nephrology·Ruth M TarziCharles D Pusey
Aug 23, 2011·Autoimmunity Reviews·Nikola LepsePeter Heeringa
Mar 12, 2011·Fertility and Sterility·Carolina Giordani AndreoliJoão Sabino Cunha-Filho
Jul 22, 2010·Autoimmunity Reviews·Nasr Y A HemdanUlrich Sack
Oct 7, 2015·Cytokine·Kritika Ramani, Partha S Biswas
Apr 2, 2016·Autoimmune Diseases·Durga Prasanna MisraRamnath Misra
Apr 2, 2011·Clinical and Experimental Immunology·C O S Savage
Sep 11, 2014·British Journal of Pharmacology·K KöckJ E Towne
Oct 17, 2013·Clinical and Experimental Immunology·G A RamirezA A Manfredi
May 5, 2016·Neurology. Neuroimmunology and Neuroinflammation·Vivien ThomEva Tolosa
Sep 28, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andreas KronbichlerMichael Rudnicki

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