Serum IL-18 and IL-18BP levels in patients with Chikungunya virus infection

Viral Immunology
Chintana ChirathawornYong Poovorawan

Abstract

Chikungunya virus infection has recently emerged in several countries. The inflammatory response is suggested to be involved in the pathology observed in this infectious disease. Interleukin-18 (IL-18) is an inducer of interferon-gamma (IFN-gamma) production and has been shown to play a role in several inflammatory diseases. IL-18 binding protein (IL-18BP) is a natural regulator of IL-18. In this study, we determined the levels of IL-18 and IL-18BP in patients with Chikungunya virus infection. Acute and convalescent sera were collected from each patient. The levels of both IL-18 and IL-18BP were measured by ELISA assays. IL-18 and IL-18BP levels were higher in patients than in controls. In addition, the level of IL-18 was higher in convalescent than in acute sera. However, the level of IL-18BP was lower in convalescent than in acute sera. These data suggest that production of both IL-18 and IL-18BP was induced following Chikungunya virus infection. IL-18BP was increased to regulate the activity of IL-18. The ratio of IL-18 to IL-18BP was higher in convalescent than in acute sera. The lower level of IL-18BP in convalescent sera was probably due to loss following IL-18 neutralization. Our data suggest that Chikungunya virus infec...Continue Reading

References

May 4, 2001·FEMS Immunology and Medical Microbiology·A S MustafaU C Chaturvedi
Jun 16, 2001·Clinical Biochemistry·P M Jacobson Brown, M G Neuman
Jan 4, 2007·Clinical Science·Ulrich Spengler, Jacob Nattermann
Jan 30, 2008·Indian Journal of Medical Microbiology·M ChhabraS Lal
Jul 11, 2008·Immunological Reviews·William P ArendCem Gabay
Sep 18, 2008·Allergology International : Official Journal of the Japanese Society of Allergology·Takeshi KimuraNaomi Kondo
Oct 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Qizhen CaoXiaoyuan Chen
Dec 24, 2008·Proceedings of the National Academy of Sciences of the United States of America·Brian KrummJunpeng Deng
Jan 22, 2009·PloS One·Lisa F P NgYee-Sin Leo
Feb 12, 2009·Journal of Biosciences·A B Sudeep, D Parashar
Jun 13, 2009·Arthritis Research & Therapy·Cem Gabay, Iain B McInnes

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Citations

Jun 17, 2010·Nature Reviews. Microbiology·Olivier Schwartz, Matthew L Albert
May 9, 2012·Nature Reviews. Rheumatology·Andreas SuhrbierPhilippe Gasque
Aug 23, 2011·PLoS Neglected Tropical Diseases·Alyson A KelvinSalvatore Rubino
Apr 6, 2012·PLoS Neglected Tropical Diseases·Laurence Dupuis-MaguiragaPierre Roques
Jun 16, 2015·Vaccine·Jorge A Salazar-GonzálezSergio Rosales-Mendoza
Jan 31, 2015·The Journal of Infectious Diseases·Terk-Shin TengLisa F P Ng
Jun 26, 2013·Asian Pacific Journal of Tropical Medicine·Chintana ChirathawornNorra Wuttirattanakowit
Jul 16, 2019·Critical Care Medicine·Pratik Sinha, Carolyn S Calfee
Dec 5, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Teck-Hui TeoLisa F P Ng
Sep 15, 2017·Viral Immunology·Sarika AmdekarKalichamy Alagarasu
Aug 29, 2018·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Victoria K Baxter, Mark T Heise
Oct 27, 2018·Frontiers in Cellular and Infection Microbiology·Ithallo S B TanabeÊnio J Bassi
Feb 6, 2017·Science Translational Medicine·Teck-Hui TeoLisa F P Ng
Aug 7, 2015·Medical Sciences : Open Access Journal·Yi-Hao ChanLisa Fong Poh Ng
Feb 13, 2018·International Journal of Rheumatic Diseases·Shefali Khanna Sharma, Sanjay Jain
Feb 27, 2018·Oral Diseases·J C LeaoL A Gueiros
Oct 20, 2020·Archives of Virology·Chintana ChirathawornYong Poovorawan

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