Serum IL-33 Is Elevated in Children with Asthma and Is Associated with Disease Severity

International Archives of Allergy and Immunology
Sedigheh Bahrami MahnehUniversal Scientific Education and Research Network (USERN)

Abstract

The role of IL-33, a member of the IL-1 family, in airway hyperresponsiveness and asthma has still to be fully understood. This study is aimed at investigating serum IL-33 in children with asthma and its association with asthma severity. This age- and sex-matched case-control study comprised 61 children with asthma and 63 healthy controls. The mean age of the participants was 9.21 years (range: 6-14). Serum IL-33 was measured using ELISA and was compared between children with asthma and controls. In addition, the association of serum IL-33 with asthma severity was investigated. The level of serum IL-33 was significantly higher in children with asthma than in controls (15.17 ± 32.3 vs. 0.61 ± 2.16 pg/ml; p = 0.028). It was significantly increased proportionately to asthma severity, namely 9.92 ± 30.26 pg/ml in children with mild asthma, 13.68 ± 29.27 pg/ml in children with moderate asthma and 31.92 ± 41.45 pg/ml in children with severe asthma (p = 0.026). Serum IL-33 is increased in children with asthma and is associated with disease severity.

Citations

Apr 16, 2017·Allergologia et immunopathologia·Y WangS Hua
Dec 10, 2017·The Journal of Experimental Medicine·Matthew T StierR Stokes Peebles
Aug 14, 2019·Current Opinion in Pulmonary Medicine·Gail M GauvreauBeth E Davis
Jan 5, 2020·The Journal of Immunology : Official Journal of the American Association of Immunologists·Oyebola O OyesolaElia D Tait Wojno
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