Feb 7, 2012

Serum IL-33 levels are associated with liver damage in patients with chronic hepatitis B

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Juan WangYanfang Jiang

Abstract

This aim of this study was to assess the potential role of IL-33 in the pathogenic process of chronic hepatitis B (CHB). The levels of serum IL-33 and soluble ST2 (sST2) in CHB patients and healthy controls (HC) were determined using enzyme-linked-immunosorbent serologic assay, and the Th1 (IFN-γ, TNF-α, IL-2) and Th2 (IL-4, IL-6, IL-10) cytokines by cytometric bead array. It was found that the levels of serum IL-33 in CHB patients were significantly higher than that of HC at the base line, but decreased after treatment with adefovir dipivoxil for 12 weeks. The levels of serum sST2, as a decoy receptor of IL-33, were significantly higher in CHB patients than the HC. There was no correlation between the levels of serum sST2 and IL-33. The concentrations of serum Th1 (IFN-γ, IL-2) and Th2 (IL-6, IL-10) cytokines in CHB patients significantly increased after treatment compared to the baseline. These results suggest that IL-33 is involved in the pathogenesis of CHB and that adefovir dipivoxil therapy can attenuate the production of IL-33 in patients with CHB.

  • References28
  • Citations24

References

Mentioned in this Paper

Interleukins
Pathogenic Aspects
Pathogenesis
Adefovir dipivoxil
Pathogenic Organism
Recombinant Interleukin-10
Dane Particle
Hepatitis B, Chronic
Liver Damage
Interleukin-10 Binding Activity

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