Serum IL-6 levels and oxidation rate of LDL cholesterol were related to depressive symptoms independent of omega-3 fatty acids among female hospital and nursing home workers in Japan

Journal of Affective Disorders
Hirohito TsuboiKayoko Shimoi

Abstract

Chronic low-grade inflammation and oxidative stress are commonly observed in persons with depression or depressive symptoms. We explored the degree of depressive symptoms under psychological stress in relation to serum LDL oxidation, inflammatory markers, and fatty acid (FA) distribution among female population. The purpose of this study was to identify peripheral factors that are related to depressive symptoms, and to assess how each factor is related to depressive symptoms. 133 female workers in a hospital and nursing homes were recruited in Japan. Depressive symptoms were assessed using the Japanese version of the Centre for Epidemiologic Studies Depression Scale (CES-D), and perceived stress was assessed using the visual analogue scale. Cytokine levels and oxidation rate of LDL cholesterol (ox-LDL/LDL) were measured as indices of inflammation and oxidation. Omega-3 FA distribution was also measured. Path analysis and hierarchical regression analysis were used to determine if each factor was predictive of depressive symptoms. It was identified that serum ox-LDL/LDL was positively connected with depressive symptoms, but was more strongly related to perceived psychological stress. Elevated serum IL-6 was positively correlated ...Continue Reading

Citations

Apr 3, 2020·International Journal of Molecular Sciences·Emily Yi-Chih TingShih-Jen Tsai
Oct 18, 2020·International Journal of Molecular Sciences·Patrizia AmadioSilvia Stella Barbieri
Jun 25, 2021·Journal of Primary Care & Community Health·Shaimaa A A M AmerMaha Anani
Dec 4, 2020·Aging and Disease·Anwen ShaoJianmin Zhang
Aug 20, 2021·Cytokine·Robert H JenkinsSimon A Jones

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