Serum IL-6 levels are associated with significant coronary stenosis in cardiovascularly asymptomatic inner-city black adults in the US.

Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]
Shenghan LaiB Detrick

Abstract

The objective of this study was to explore whether increased levels of inflammatory cytokines are associated with the risk of clinically silent coronary artery disease. Three-hundred-fifty-six black adults aged 25-54 residing in inner city of Baltimore, Maryland, United States were included in this study. Sociodemographics were assessed as were lipid profiles, IL-6, tumor necrosis factor-alpha (TNF-alpha), soluble intercellular adhesion molecule-1 (sICAM-1), and high-sensitivity C-reactive protein (hs-CRP) levels. Computed tomography (CT) coronary angiography was performed. Coronary calcification was identified in 22.5 % participants and 14 % had significant (>or=50 %) coronary stenosis. Multiple logistic regression analyses suggested that IL-6 levels were independently associated with the presence of coronary calcification and significant coronary stenosis, while TNF-alpha, sICAM-1 and hs-CRP levels were not. This study underscores a critical role for IL-6 in atherosclerosis and suggests that IL-6 may be a marker for significant coronary stenosis in cardiovascularly asymptomatic individuals.

References

Sep 1, 1991·European Journal of Immunology·C MunozJ M Cavaillon
Jul 1, 1993·Cardiovascular Research·J Nilsson
Sep 1, 1996·Circulation·L M BiasucciA Maseri
Nov 21, 1996·The New England Journal of Medicine·R F Gillum
Nov 14, 1997·Arteriosclerosis, Thrombosis, and Vascular Biology·R T Lee, P Libby
May 29, 1998·Circulation·P W WilsonW B Kannel
Jan 14, 1999·The New England Journal of Medicine·R Ross
Oct 16, 1999·Arteriosclerosis, Thrombosis, and Vascular Biology·M ErrenP Cullen
Mar 10, 2001·Microbiology and Molecular Biology Reviews : MMBR·T H Mogensen, S R Paludan
Dec 20, 2002·Nature·Peter Libby
Jul 4, 2003·Proceedings of the National Academy of Sciences of the United States of America·Janice K Kiecolt-GlaserRonald Glaser
May 8, 2004·American Heart Journal·Keith C Ferdinand
Apr 21, 2005·European Heart Journal·Sebastian LeschkaSimon Wildermuth
Aug 2, 2005·Journal of the American College of Cardiology·Gilbert L RaffJames A Goldstein
May 12, 2006·The Neurologist·Mitchell S V Elkind
Jun 21, 2006·The American Journal of Cardiology·Enrique Z FismanAlexander Tenenbaum
Jun 24, 2006·AJR. American Journal of Roentgenology·Harpreet K PannuElliot K Fishman
Jan 2, 2007·The American Journal of Cardiology·Won-Young LeeElizabeth Barrett-Connor
Apr 20, 2007·Journal of Investigative Medicine : the Official Publication of the American Federation for Clinical Research·Muredach P ReillyDaniel J Rader
Nov 13, 2007·Experimental and Molecular Pathology·Catherine M SandersRobert E Lewis

❮ Previous
Next ❯

Citations

Mar 1, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Xiuru GuanJin Zhou
Oct 4, 2011·Vascular Health and Risk Management·Michael D BrownJoon-Young Park
Aug 8, 2014·International Journal of Environmental Research and Public Health·Xiakun ZhangLina Dong
Jun 16, 2012·PM & R : the Journal of Injury, Function, and Rehabilitation·Mallikarjuna NallegowdaGary P Foster
Nov 20, 2016·Arteriosclerosis, Thrombosis, and Vascular Biology·Albert LinWen-Chih Wu
Dec 26, 2016·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Meredith A AtkinsonEdgar R Miller

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in AS

Cell adhesion molecules expressed on the vascular endothelium and circulating leukocytes in response to inflammatory stimuli are implicated in atherosclerosis. Here is the latest research.