Serum IL10 and circulating CD4(+) CD25(high) regulatory T cell numbers as predictors of clinical outcome and survival in patients with head and neck squamous cell carcinoma

Head & Neck
Osama AlhamarnehJohn Greenman

Abstract

Patients with head and neck squamous cell carcinoma (HNSCC) commonly have an imbalance in T helper (Th)1/Th2-type cytokines and elevated levels of CD4(+) CD25(high) regulatory T cells (Treg). Here, we investigated the association of circulating interleukin (IL)10, IL12, and Treg-cells with clinical outcome in patients with HNSCC. Serum cytokine levels were determined by enzyme-linked immunosorbent assay (ELISA) in patients' pretreatment (n = 107) and 4 to 6 weeks posttreatment (n = 43), and in nontumor controls (n = 40). Treg-cell levels were determined by flow cytometry. IL10 detectability was significantly higher in patients than controls (p = .001). Pretreatment IL10 levels in all anatomical subsites, except the oral cavity, were significantly elevated in stages III/IV, N+ patients, and in T3/4-tumors (p = .005, .037, and .001, respectively). The detectability of IL10 significantly correlated with poorer survival after a maximum follow-up of 36 months. Treg-cell levels did not correlate with any clinical parameters. IL10 is a potential independent factor in predicting a poor clinical outcome in newly presenting tumors of laryngeal and pharyngeal origin. The role of circulating Treg-cells as predictors of clinical outcome req...Continue Reading

References

Jan 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·A SicaA Mantovani
Jun 3, 2000·Annual Review of Immunology·E M Shevach
Aug 18, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·B C SheuS C Huang
Aug 2, 2002·The Laryngoscope·Stephen W ChandlerBarbara S Ducatman
Aug 24, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·David J CousinsDontcho Z Staynov
Jul 15, 2003·Proceedings of the National Academy of Sciences of the United States of America·Ludger KleinHarald von Boehmer
Jun 3, 2004·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Iris KussTheresa L Whiteside
Nov 4, 2004·Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery·Anthony SparanoM Rita I Young
Dec 6, 2005·Cancer Immunology, Immunotherapy : CII·Koji KonoHideki Fujii
Jun 21, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Ilona KryczekWeiping Zou
Oct 17, 2006·The Journal of Laryngology and Otology·A JebreelJ Greenman
Oct 24, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fabienne VenetGuillaume Monneret
Dec 22, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Yijun CarrierHoward L Weiner
Jan 16, 2007·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Faina LinkovRobert L Ferris
Apr 4, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dolgor BaatarArya Biragyn
Nov 3, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Laura StraussTheresa L Whiteside
Apr 17, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Sylvain LadoireFrançois Ghiringhelli
May 20, 2008·Lancet·Athanassios ArgirisRobert L Ferris
Jun 19, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Christoph BergmannTheresa L Whiteside
Sep 19, 2008·Cancer·David M CognettiStephen Y Lai
Oct 10, 2008·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Greg P BertenshawBrian C Mansfield
Aug 20, 2009·Current Molecular Medicine·Jay A Berzofsky, Masaki Terabe
Feb 12, 2010·Annals of the New York Academy of Sciences·David J DiLilloThomas F Tedder

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Citations

Sep 15, 2011·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Bastian SchillingTheresa L Whiteside
Jan 1, 2011·Results in Immunology·Victoria L GreenNicholas D Stafford
Aug 16, 2017·Oncoimmunology·Daniele MaggioniWerner Garavello
Nov 22, 2018·Frontiers in Oncology·Caoimhín O'HigginsRasha Abu Eid
Dec 13, 2018·Journal of Immunology Research·Mircea TampaSimona Roxana Georgescu
Apr 9, 2020·Frontiers in Oncology·Jian ZhouLi-Ming Lu
Nov 19, 2020·Cancers·Panagiota EconomopoulouAmanda Psyrri

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