Serum immune complexes and disease

Australian and New Zealand Journal of Medicine
A J WoodroffeA R Clarkson


The solid phase Clq radioimmunoassay was used to detect immune complexes in sera from patients with systemic lupus erythematosus (14/25), rheumatoid arthritis (4/5), vasculitis (5/15), infective endocarditis (2/2), acute rheumatic fever (2/3), pre-eclamptic toxaemia (0/14), lung cancer (3/7), glomerulonephritis (26/98) and renal transplant patients (0/5). The best correlation with disease activity was seen in systemic lupus erythematosus and infective endocarditis where serial immune complex determinations were clearly of value in monitoring therapy. The findings in primary glomerulonephritis indicate only a limited usefulness of the assay in that serum immune complexes were detected in a minority (22/73) of patients with glomerular immune deposits. In particular the data do not support a role for Clq fixing immune complexes in the pathogenesis of membranous glomerulonephritis or in pre-eclamptic toxaemia.


Mar 12, 1977·Lancet·R J LevinskyJ F Soothill
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Apr 1, 1985·European Journal of Obstetrics, Gynecology, and Reproductive Biology·M H Houwert-de JongH J Schuurman
May 1, 1984·Journal of Reproductive Immunology·A AlanenO Wager
Apr 1, 1979·Australian and New Zealand Journal of Medicine·J V Wells
Jan 1, 1984·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·K M BannisterA J Woodroffe
Sep 1, 1980·Kidney International·A J WoodroffeA R Clarkson
Oct 3, 2006·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Amit MayerMoshe Mazor
Jan 1, 1981·American Journal of Reproductive Immunology : AJRI·A N TheofilopoulosF J Dixon
Feb 1, 1982·Australian and New Zealand Journal of Medicine·M D SmithR Rowland
Aug 1, 1982·Australian and New Zealand Journal of Medicine·K N LaiA R Clarkson
Oct 1, 1980·Australian and New Zealand Journal of Medicine·G CarneyJ R Lawrence
Jan 1, 1981·Critical Reviews in Clinical Laboratory Sciences·D F Keren
Aug 1, 1982·Seminars in Arthritis and Rheumatism·B M Rothschild, A T Masi

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