PMID: 3789816Oct 1, 1986Paper

Serum immune complexes containing IgA appear to predict erosive arthritis in a longitudinal study in rheumatoid arthritis

Annals of the Rheumatic Diseases
M L WestedtA Cats

Abstract

Fifty seven patients with rheumatoid arthritis (RA) were studied longitudinally, and the presence of rheumatoid factor (RF) and various types of immune complexes (IC) was correlated with joint activity and the presence of extra-articular features (EAF). In a cross sectional study it was found that the levels of circulating IC and RF correlated significantly with joint disease activity and the presence of EAF. Longitudinally, levels of IC measured by the C1q binding activity and IC containing IgG and IgM correlated significantly with fluctuations in joint disease activity, whereas IC containing IgG and IgA correlated with the occurrence of EAF. RF and IC levels, however, did not predict the clinical course of the disease. IC containing C3 and C4 were found infrequently and were only present in patients with active rheumatoid vasculitis (RV). The continuous presence of these IC appeared to be linked to the recurrence of vasculitis, irrespective of treatment. Significantly more erosions of hands and feet were found after one year follow up in those RA patients who presented early (disease duration less than one year) who initially had a raised serum IgA IC level (r = 0.72; p less than 0.005).

References

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Citations

Sep 1, 1988·Clinical Rheumatology·T D Spector, D L Scott
Oct 10, 1987·Lancet·H ValdimarssonT Jónsson
May 1, 1987·Annals of the Rheumatic Diseases·J A ArnasonH Valdimarsson
Mar 1, 1988·Annals of the Rheumatic Diseases·T T MöttönenM Oka
May 1, 1991·Annals of the Rheumatic Diseases·S O'Mahony, A Ferguson
Jan 1, 1990·Rheumatology International·F EggelmeijerF C Breedveld
Feb 10, 1998·The American Journal of Medicine·G S Alarcón
Jan 1, 1988·Scandinavian Journal of Rheumatology. Supplement·T MöttönenM Oka
Feb 1, 2000·Baillière's Best Practice & Research. Clinical Rheumatology·P G ConaghanP Emery
Feb 1, 1992·Baillière's Clinical Rheumatology·F A Wollheim, K B Eberhardt
Nov 1, 1990·Arthritis and Rheumatism·C E SiegertF C Breedveld
Jul 18, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lydia P van der SteenMarjolein van Egmond
Oct 20, 2018·Frontiers in Immunology·Josephine NehringMarten Trendelenburg

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