Serum immunoglobulin G, M and A response to Cryptosporidium parvum in Cryptosporidium-HIV co-infected patients.

BMC Infectious Diseases
Kirti KaushikNancy Malla

Abstract

Cryptosporidium parvum, the protozoan parasite, causes a significant enteric disease in immunocompromised hosts such as HIV patients. The present study was aimed to compare serum IgG, IgM and IgA responses to crude soluble antigen of C. parvum in HIV seropositive and seronegative patients co-infected with Cryptosporidium and to correlate the responses with symptomatology. Cryptosporidium parvum specific serum antibody (IgG, IgM and IgA) responses were assessed by ELISA in 11 HIV seropositive Cryptosporidium positive (Group I), 20 HIV seropositive Cryptosporidium negative (Group II), 10 HIV seronegative Cryptosporidium positive (Group III), 20 HIV seronegative Cryptosporidium negative healthy individuals (Group IV) and 25 patients with other parasitic diseases (Group V). A positive IgG and IgA antibody response was observed in significantly higher number of Cryptosporidium infected individuals (Gp I and III) compared to Cryptosporidium un-infected individuals (Gp II, IV and V) irrespective of HIV/immune status. Sensitivity of IgG ELISA in our study was found to be higher as compared to IgM and IgA ELISA. The number of patients with positive IgG, IgM and IgA response was not significantly different in HIV seropositive Cryptospori...Continue Reading

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Citations

Dec 18, 2012·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Poonum S KorpeWilliam A Petri
May 29, 2014·The American Journal of Tropical Medicine and Hygiene·Jane W WanyiriHonorine D Ward
Nov 23, 2017·BMC Pulmonary Medicine·Richard KwizeraDavid W Denning
Aug 18, 2020·Journal of Parasitic Diseases : Official Organ of the Indian Society for Parasitology·Dina AboelsouedKadria N Abdel Megeed
Jun 28, 2021·Parasites & Vectors·Xue-Mei WuGuang-Hui Zhao

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Methods Mentioned

BETA
ELISA
PCR

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