Serum immunoglobulin levels and malaria antibodies in Burkitt's lymphoma

Transactions of the Royal Society of Tropical Medicine and Hygiene
F NkrumahS E Maddison

Abstract

Data are presented to support a relationship between malaria infection and Burkitt's lymphoma in African children. IgG, IgM and IgA levels were measured in sera from Burkitt's lymphoma patients and from sex- and age-matched, nearest-neighbour controls. All three classes of immunoglobulins were present in significantly lower amounts in the sera from Burkitt's lymphoma patients than in the sera from controls. The mechanism of this apparent B-cell suppression is not yet clear. Malaria-specific IgG and IgM antibody titres were determined in the indirect immunofluorescence test. No significant difference in the IgG malaria-specific antibodies was detected between the two groups of sera. Malaria antibody levels measured using IgM specific conjugates were significantly lower in the sera from Burkitt's lymphoma patients in reactions with Plasmodium falciparum antigen. No significant difference was observed when P. malariae was used. Confirmation of this finding would serve as a positive link between Burkitt's lymphoma and P. falciparum infection.

References

Dec 25, 1975·The New England Journal of Medicine·G Klein
Jan 15, 1976·International Journal of Cancer. Journal International Du Cancer·P GerberE Kieff
Apr 15, 1976·International Journal of Cancer. Journal International Du Cancer·W LeiboldG Klein
Jun 30, 1975·Annals of the New York Academy of Sciences·C B ReimerB E McGrew
Mar 1, 1976·Journal of the National Cancer Institute·R H MorrowP G Smith
Jan 22, 1972·Lancet·B M GreenwoodA Palit
Feb 21, 1970·Lancet·P J FialkowP Clifford
Mar 28, 1970·Lancet·M W Steele
Oct 10, 1970·Lancet·A M Stewart
Jul 15, 1970·International Journal of Cancer. Journal International Du Cancer·G W Kafuko, D P Burkitt
Sep 1, 1973·Proceedings of the National Academy of Sciences of the United States of America·T ShopeG Miller
Sep 15, 1973·International Journal of Cancer. Journal International Du Cancer·M A EpsteinH Rabin
Jul 1, 1974·The American Journal of Tropical Medicine and Hygiene·P M Feorino, H M Mathews
Oct 1, 1974·Cancer·W Henle, G Henle
Sep 1, 1974·Cellular Immunology·A U Krettli, R Nussenzweig
Jan 1, 1972·Transactions of the Royal Society of Tropical Medicine and Hygiene·J L ZieglerR Woods
Aug 1, 1971·Experimental Parasitology·R C SengersW H Doesburg
Sep 1, 1965·Immunochemistry·G ManciniJ F Heremans
Mar 1, 1970·Cancer·J L ZieglerP P Carbone
Jan 1, 1995·Journal of Neuro-oncology·R M BashirM X Wei
Nov 1, 1958·The British Journal of Surgery·D BURKITT
Feb 1, 1972·California Medicine·R J Boese

❮ Previous
Next ❯

Citations

Dec 21, 2016·International Journal of Cancer. Journal International Du Cancer·Mette Ø AgerbaekAli Salanti
Jun 2, 2011·International Journal of Cancer. Journal International Du Cancer·Mercy Guech-OngeySam M Mbulaiteye
Aug 15, 1984·International Journal of Cancer. Journal International Du Cancer·R J BiggarW A Blattner
Mar 7, 2020·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·Maria Del Pilar QuintanaLars Hviid

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

California Medicine
R J Boese
Clinical Chemistry and Laboratory Medicine : CCLM
Randi E GislefossLars Mørkrid
International Journal of Cancer. Journal International Du Cancer
Mercy Guech-OngeySam Mbulaiteye
© 2021 Meta ULC. All rights reserved